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9.A.78.1.1
Membrane-associated phosphatidylinositol transfer protein 1, PITPNM1, of 1244 aas and possibly 8 TMSs in a 4 + 4 TMS arrangement. It catalyzes the transfer of phosphatidylinositol (PI) between membranes (Garner et al. 2012, Fullwood et al. 1999). It binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (Garner et al. 2012) and regulates RHOA activity while playing a role in cytoskeleton remodeling (Tian et al. 2002). It is necessary for normal completion of cytokinesis (Litvak et al. 2004) and plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (Litvak et al. 2005). It seems to be necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (Amarilio et al. 2005) and is required for protein export from the endoplasmic reticulum and the Golgi (Litvak et al. 2005). It binds calcium ions (Lev et al. 1999).

Accession Number:O00562
Protein Name:Membrane-associated phosphatidylinositol transfer protein 1
Length:1244
Molecular Weight:134848.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

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FASTA formatted sequence
1:	MLIKEYHILL PMSLDEYQVA QLYMIQKKSR EESSGEGSGV EILANRPYTD GPGGSGQYTH 
61:	KVYHVGSHIP GWFRALLPKA ALQVEEESWN AYPYTRTRYT CPFVEKFSIE IETYYLPDGG 
121:	QQPNVFNLSG AERRQRILDT IDIVRDAVAP GEYKAEEDPR LYHSVKTGRG PLSDDWARTA 
181:	AQTGPLMCAY KLCKVEFRYW GMQAKIEQFI HDVGLRRVML RAHRQAWCWQ DEWTELSMAD 
241:	IRALEEETAR MLAQRMAKCN TGSEGSEAQP PGKPSTEARS AASNTGTPDG PEAPPGPDAS 
301:	PDASFGKQWS SSSRSSYSSQ HGGAVSPQSL SEWRMQNIAR DSENSSEEEF FDAHEGFSDS 
361:	EEVFPKEMTK WNSNDFIDAF ASPVEAEGTP EPGAEAAKGI EDGAQAPRDS EGLDGAGELG 
421:	AEACAVHALF LILHSGNILD SGPGDANSKQ ADVQTLSSAF EAVTRIHFPE ALGHVALRLV 
481:	PCPPICAAAY ALVSNLSPYS HDGDSLSRSQ DHIPLAALPL LATSSSRYQG AVATVIARTN 
541:	QAYSAFLRSP EGAGFCGQVA LIGDGVGGIL GFDALCHSAN AGTGSRGSSR RGSMNNELLS 
601:	PEFGPVRDPL ADGVEGLGRG SPEPSALPPQ RIPSDMASPE PEGSQNSLQA APATTSSWEP 
661:	RRASTAFCPP AASSEAPDGP SSTARLDFKV SGFFLFGSPL GLVLALRKTV MPALEAAQMR 
721:	PACEQIYNLF HAADPCASRL EPLLAPKFQA IAPLTVPRYQ KFPLGDGSSL LLADTLQTHS 
781:	SLFLEELEML VPSTPTSTSG AFWKGSELAT DPPAQPAAPS TTSEVVKILE RWWGTKRIDY 
841:	SLYCPEALTA FPTVTLPHLF HASYWESADV VAFILRQVIE KERPQLAECE EPSIYSPAFP 
901:	REKWQRKRTQ VKIRNVTSNH RASDTVVCEG RPQVLSGRFM YGPLDVVTLT GEKVDVYIMT 
961:	QPLSGKWIHF GTEVTNSSGR LTFPVPPERA LGIGVYPVRM VVRGDHTYAE CCLTVVARGT 
1021:	EAVVFSIDGS FTASVSIMGS DPKVRAGAVD VVRHWQDSGY LIVYVTGRPD MQKHRVVAWL 
1081:	SQHNFPHGVV SFCDGLTHDP LRQKAMFLQS LVQEVELNIV AGYGSPKDVA VYAALGLSPS 
1141:	QTYIVGRAVR KLQAQCQFLS DGYVAHLGQL EAGSHSHASS GPPRAALGKS SYGVAAPVDF 
1201:	LRKQSQLLRS RGPSQAEREG PGTPPTTLAR GKARSISLKL DSEE