TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.17.1.1









Vesicle-associated membrane protein-associated protein-B/C, VAMP-B/C or VAPB). It has 243aas with has one C-terminal TMS with the large N-terminal domain extracellular. It binds to several organelle-resident membrane proteins to mediate ER-organelle tethering. Mutations give rise toamyotrophic lateral sclerosis (ALS) because the mutant proteins induce protein misfolding and aggregation, leading to ER disorganization. Thus, altered ER domain properties and impaired ER-organelle tethering result (Yamanaka et al. 2020).

Eukaryota
Metazoa
VAPB of Homo sapiens (O95292)
9.B.17.1.2









Plant VAMP (vesicle-associated membrane protein) family protein of 220 aas and one C-terminal TMS.

Eukaryota
Viridiplantae
VAMP of Arabidopsis thaliana
9.B.17.1.3









Motile sperm domain-containing protein 2, MSDP2, of 523 aas and one C-terminal TMS.

Eukaryota
Opisthokonta
MSDP2 of Cyprinodon tularosa