TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.17.1.1









Vesicle-associated membrane protein-associated protein-B/C, VAMP-B/C or VAPB). It has 243aas with has one C-terminal TMS with the large N-terminal domain extracellular. It binds to several organelle-resident membrane proteins to mediate ER-organelle tethering. Mutations give rise toamyotrophic lateral sclerosis (ALS) because the mutant proteins induce protein misfolding and aggregation, leading to ER disorganization. Thus, altered ER domain properties and impaired ER-organelle tethering result (Yamanaka et al. 2020).

Eukaryota
Metazoa
VAPB of Homo sapiens (O95292)
9.B.17.1.2









Plant VAMP (vesicle-associated membrane protein) family protein of 220 aas and one C-terminal TMS.

Eukaryota
Viridiplantae
VAMP of Arabidopsis thaliana
9.B.17.1.3









Motile sperm domain-containing protein 2, MSDP2, of 523 aas and one C-terminal TMS.

Eukaryota
Opisthokonta
MSDP2 of Cyprinodon tularosa
9.B.17.1.4









MSP (Major sperm protein) domain protein of 224 aas and 1 or 2 TMSs.

Eukaryota
Sar
MSP protein of Theileria parva strain Muguga
9.B.17.1.5









Uncharacterized protein of 216 aas and 1 TMS

Eukaryota
Discoba
UP of Trypanosoma brucei gambiense
9.B.17.1.6









Uncharacterized protein of 392 aas and 1 (C-terminal) or 2 (N-terminal) TMSs

Eukaryota
Opisthokonta
UP of Jimgerdemannia flammicorona
9.B.17.1.7









Vesicle-associated protein 4-2-like of 267aas and possibly 1 or 2 TM

Eukaryota
Viridiplantae
VAP of Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
9.B.17.2.1









Sec14-like protein1, Sec14L1 of 715 aas and 0 TMSs. It may play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, it functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. It prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (Li et al. 2013). It may also regulate the SLC18A3 and SLC5A7 cholinergic transporters (Ribeiro et al. 2007). It contains a Golgi Dynamics (GOLD) domain (Mendes and Costa-Filho 2022).

Eukaryota
Opisthokonta
Sec14L1 of Homo sapiens
9.B.17.2.2









Sec14L4 of 406 aas and 0 TMSs. It is a probable hydrophobic ligand-binding protein that may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Eukaryota
Opisthokonta
Sec14L4 of Homo sapiens
9.B.17.2.3









ACBD3 (GCP60, GOCAP1, GOLPH1) of 528 aas and one N-terminal TMS.  It is involved in the maintenance of the Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (Sohda et al. 2001).

Eukaryota
Opisthokonta
ACBD3 of Homo sapiens
9.B.17.2.4









FYVE and coiled-coil domain-containing protein 1, FYCO1, of 1478 aas and possibly two TMSs near the C-terminus of the protein.  A mutation in the FYCO1 gene causes congenital cataracts (Mei et al. 2022).

Eukaryota
Opisthokonta
FYCO1 of Homo sapiens