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9.B.188 The Transmembrane Emp24 Domain-containing Protein (TMED) Family 

Members of this family are involved in vesicular protein trafficking and mainly function in the early secretory pathway, but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane, thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in the organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (Beck et al. 2009). The p24/transmembrane emp24 domain (TMED) family of cargo receptors has been shown to be important in development and disease and has been reviewed (Aber et al. 2019).

References associated with 9.B.188 family:

Aber, R., W. Chan, S. Mugisha, and L.A. Jerome-Majewska. (2019). Transmembrane emp24 domain proteins in development and disease. Genet Res (Camb) 101: e14. 31878985
Bartoszewski, S., S. Luschnig, I. Desjeux, J. Grosshans, and C. Nüsslein-Volhard. (2004). Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed Tkv receptor during early embryogenesis. Mech Dev 121: 1259-1273. 15327786
Carney, G.E. and N.J. Bowen. (2004). p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities. Biol Cell 96: 271-278. 15145531
Hou, W. and L.A. Jerome-Majewska. (2018). TMED2/emp24 is required in both the chorion and the allantois for placental labyrinth layer development. Dev Biol 444: 20-32. 30236446
Hou, W., S. Gupta, M.C. Beauchamp, L. Yuan, and L.A. Jerome-Majewska. (2017). Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2. PLoS One 12: e0182995. 28797121
Kondylis, V., Y. Tang, F. Fuchs, M. Boutros, and C. Rabouille. (2011). Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. PLoS One 6: e17173. 21383842
Li, X., Y. Wu, C. Shen, T.Y. Belenkaya, L. Ray, and X. Lin. (2015). Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway. Biochem. Biophys. Res. Commun. 463: 483-489. 26002470
Luo, W., Y. Wang, and G. Reiser. (2011). Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. J Neurochem 117: 71-81. 21219331
Nie, Z.W., Y.J. Niu, W. Zhou, D.J. Zhou, J.Y. Kim, and X.S. Cui. (2020). AGS3-dependent TGN-membrane trafficking is essential for compaction in mouse embryos. J Cell Sci. [Epub: Ahead of Print] 33148610
Salnikov, E.S., C. Aisenbrey, B. Pokrandt, B. Brügger, and B. Bechinger. (2019). Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24. Front Mol Biosci 6: 83. 31608287