9.B.188.1.3
The transmembrane (2 TMSs, N- and C-termini) Emp24 domain-containing protein 3, TMED3 of 217 aas. TMED3 plays a role in esophageal carcinomas (Kattner 2023). It has a potential role in vesicular protein trafficking, mainly in the early
secretory pathway, and it contributes to the coupled localization of TMED2 and
TMED10 in the cis-Golgi network (Emery et al. 2000). It may regulate the progression of breast cancer (Yang et al. 2023).
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| Accession Number: | Q9Y3Q3 |
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| Protein Name: | Transmembrane emp24 domain-containing protein 3 |
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| Length: | 217 |
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| Molecular Weight: | 24777.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum-Golgi intermediate compartment membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGSTVPRSAS VLLLLLLLRR AEQPCGAELT FELPDNAKQC FHEEVEQGVK FSLDYQVITG
61: GHYDVDCYVE DPQGNTIYRE TKKQYDSFTY RAEVKGVYQF CFSNEFSTFS HKTVYFDFQV
121: GDEPPILPDM GNRVTALTQM ESACVTIHEA LKTVIDSQTH YRLREAQDRA RAEDLNSRVS
181: YWSVGETIAL FVVSFSQVLL LKSFFTEKRP ISRAVHS