9.B.188.1.5
Transmembrane emp24 domain-containing protein, eclair or Eca, of 216 aas and 2 TMSs, N- and C-terminal. Eca and Bai are essential, though not redundant,
for dorsoventral patterning of the embryo. They are required during
early embryogenesis for the activity of maternal Tkv receptor (TC# 8.B.23.1.27), while the zygotic Tkv is not affected (Bartoszewski et al. 2004). It may also be involved in Golgi organization (Kondylis et al. 2011). Ecla and Bai are involved in the early secretory pathway of Wingless/Wnt, but only Bai interacts with wingless (Wg) (Li et al. 2015).
|
| Accession Number: | Q9I7K5 |
|---|
| Protein Name: | Transmembrane emp24 domain-containing protein eca |
|---|
| Length: | 216 |
|---|
| Molecular Weight: | 25159.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Number of TMSs: | 2 |
|---|
| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
|---|
| Substrate |
|
|---|
1: MRDQFISLAL ILCVLHSACG LYFHISETER KCFIEEVPDE TTVIVNYKVE LYDPRSNGFM
61: PSSPGIGMHV EVRDSDDKIV LSRVYSSQGR ISFTSHTPGE HVICMFSNST AWFSGAQLRV
121: HLDIQVGEHA IDYAHVAQKE KLTELQLRIR QLLDQVEQIT KEQNYQRYRE ERFRHTSEST
181: NSRVLWWSLA QTVVLVCMGF WQMRHLKSFF EAKKLV