| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.23.1.1 | TMEM106B (transmembrane protein 106B) plays an integral role in microglia and oligodendrocyte function (Lok and Kwok 2021). It is of 274 aas with 1 or 2 TMSs. It is involved in several diseases and is linked to cell death (see family description) (Nicholson and Rademakers 2016). It exerts its effects on FTLD-TDP disease risk through alterations in lysosomal pathways, and TMEM106B and C9orf72 may interact in FTLD-TDP pathophysiology (Busch et al. 2016). Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation (Bauer et al. 2022). The TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia (Marks et al. 2024). | Eukaryota |
Metazoa, Chordata | TMEM106B of Homo sapiens |
|
9.B.23.1.2 | Putative serine endopeptidase (DUF1356) of 466 aas and 2 - 5 TMSs. | Eukaryota |
Viridiplantae, Chlorophyta | Putative endopeptidase of Chlorella variabilis (Green alga) |
|
9.B.23.1.3 | Uncharacterized protein of 248 aas and 1 TMS. | Eukaryota |
Viridiplantae, Chlorophyta | UP of Chlamydomonas reinhardtii (Chlamydomonas smithii) |
|
9.B.23.1.4 | TMEM106C of 250 aas and 2 TMSs. TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma (HCC) (Duan et al. 2021). TMEM106C is overexpressed in HCC, and its inhibition suppresses the proliferation and metastasis of HCC. Upregulation of TMEM106C correlated with sex, tumor stage, tumor grade and prognosis. Overexpression of TMEM106C was linked to functional networks involving organelle fission and cell cycle signaling pathways (Duan et al. 2021). | Eukaryota |
Metazoa, Chordata | TMEM23C of Homo sapiens |
|
9.B.23.1.5 | TMEM106A of 262 aas and 2 separated but fairly central TMSs. See paragraph 3 in the family description for details of studies and references. | Eukaryota |
Metazoa, Chordata | TMEM106A of Homo sapiens |
|
9.B.23.1.6 | TMEM106A of 245 aas and 1 central TMS. | Eukaryota |
Metazoa, Platyhelminthes | TMEM106A of Echinococcus granulosus |
|
9.B.23.3.1 | Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family isoform 1 of 250 aas and 1 TMS. | Eukaryota |
Viridiplantae, Streptophyta | LEA protein of Morus notabilis |
|
9.B.23.3.2 | Uncharacterized protein of 226 aas and 1 TMS | Eukaryota |
Viridiplantae, Streptophyta | UP of Prunus persica (Peach) (Amygdalus persica) |
|
9.B.23.3.3 | Uncharacterized protein of 221 aas and 1 TMS. | Eukaryota |
Viridiplantae, Streptophyta | UP of Ricinus communis (Castor bean) |
|
9.B.23.4.1 | Uncharacterized protein of 256 aas and 1 TMS. | Eukaryota |
Viridiplantae, Streptophyta | UP OF Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) |
|
9.B.23.4.2 | Uncharacterized protein of 641 aas and 1 TMS. The C-terminal domain (residues 180 - end) is homologous to TMEM106 proteins while the N-terminus (residues 181 - 170 is proline-rich and is homologous to members of the late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family. | Eukaryota |
Viridiplantae, Streptophyta | UP of Setaria italica (Foxtail millet) (Panicum italicum) |
|
9.B.23.4.3 | NDR1/HIN1-like (NHL) protein of 238 aas with 1 huge TMS. | None |
Viridiplantae, Streptophyta | NHL protein of Drosera capensis |
|
9.B.23.4.4 | Ndr1/hin1-like (NHL) protein of 454 aas and 1 huge TMS. | None |
NHL of Anaeramoeba ignava | |
|
9.B.23.4.5 | NDR1/HIN1-like (NHL) protein of 210 aas and 1 huge TMS. | None |
Viridiplantae, Streptophyta | NHL protein of Vitis vinifera |
|
9.B.23.4.6 | NDR1/HIN1-like (NHL) protein of 246 aas with 1 huge TMS. | None |
Viridiplantae, Streptophyta | NHL of Vigna angularis |