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9.B.23.1.1
TMEM106B (transmembrane protein 106B) plays an integral role in microglia and oligodendrocyte function (Lok and Kwok 2021). It is of 274 aas with 1 or 2 TMSs. It is involved in several diseases and is linked to cell death (see family description) (Nicholson and Rademakers 2016). It exerts its effects on FTLD-TDP disease risk through alterations in lysosomal pathways, and TMEM106B and C9orf72 may interact in FTLD-TDP pathophysiology (Busch et al. 2016).

Accession Number:Q9NUM4
Protein Name:Transmembrane protein 106B
Length:274
Molecular Weight:31127.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Late endosome membrane1 / Single-pass type II membrane protein2
Substrate NONE

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FASTA formatted sequence
1:	MGKSLSHLPL HSSKEDAYDG VTSENMRNGL VNSEVHNEDG RNGDVSQFPY VEFTGRDSVT 
61:	CPTCQGTGRI PRGQENQLVA LIPYSDQRLR PRRTKLYVMA SVFVCLLLSG LAVFFLFPRS 
121:	IDVKYIGVKS AYVSYDVQKR TIYLNITNTL NITNNNYYSV EVENITAQVQ FSKTVIGKAR 
181:	LNNITIIGPL DMKQIDYTVP TVIAEEMSYM YDFCTLISIK VHNIVLMMQV TVTTTYFGHS 
241:	EQISQERYQY VDCGRNTTYQ LGQSEYLNVL QPQQ