9.B.311.1.32
Sphingosine N-acyltransferase, lac1, of 475 aas and 7 TMSs in a 6 + 1 TMS arrangement. It may also be a sugar transporter, Lac1, in the ER. It is essential for cellulase
production and biomass formation by affecting protein processing in the ER
(particularly protein glycosylation) and lipid biosynthesis. The effect
of LAC1 on cellulase production seems to be post-transcriptional at a late
stage of cellulase production, independent on the well-known cellulase
regulation mediated by CRT1 and XYR1 (Wang et al. 2022).
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| Accession Number: | OTA00675.1 |
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| Protein Name: | OTA00675.1 sphingosine N-acyltransferase lac1 [Trichoderma parareesei] |
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| Length: | 476 |
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| Molecular Weight: | |
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| Species: | Trichoderma parareesei [858221] |
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| Number of TMSs: | 6 |
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| Substrate |
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1: MGDSHGLASE KTATGSSMAP QSSSRPANGV PNGSLYLQAS GSNGNVVLVR RLRRKDEGLW
61: KPLARWFVEN QVGLSLNLLA LLFLSHACIP KAREYTTKFF HLSYYNGKTG KYATGFDDAY
121: LIAFFIVLFT GLRAGTMEYI LAPLGRLNGI SKRKDVTRFS EQAWLLVYYA VFWPTGVYLY
181: YNSPAYLNLR ELWTDWPNRE MGGLMKWYML AQWAFWLQQI VVINIEDRRK DHWQMFSHHL
241: ITTALISSCY CYHHTRVGMF ILVIMDVVDL FLPLAKCLKY CGFSTLCDVT FGLFMVTWFI
301: ARHVFYLAVC WSIYAHTPEI MPNGCFAGPN SSLQGPFEAP SGFTYLIEPF FNSTGRVCYN
361: ETVKWAFLTP LLLLQGITIF WFCMIVRVAI KVLRGDGAED TRSDDEGEEG EDEEELIYEE
421: VQPLEQEVGV EELDLKSWER RNGLKKQVSA SGVSLPGHSD RKELLGRIGC EKQVE