9.b.369. The Van Gogh-like Protein (VANGL) Family
This family consists of proteins of 400 - 600 aas with 4 closely positioned TMSs within a larger protein with both N- and C-terminal hydrophilic domains. It is called the VANGL or Strabismus family. It may function with retromer complexes to recycle intracellular vacuolar constituents. It may function with proteins such as Frzzled, Dishevelled, Diego, Flaminco, and the cargo adaptor protein, SNx27.