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9.B.39.1.8
Debris buster, Dsb of 615 aas and 2 TMSs, one near the N-terminus, and one near the C-terminus. Drosophila has 14 SR-B members whose functions are not well known. It is one of the scavenger receptors class B (SR-B) which are multifunctional transmembrane proteins which in vertebrates participate in lipid transport, pathogen clearance, lysosomal delivery and intracellular sorting. Dsb sorts components of the apical extracellular matrix which are essential for airway physiology. Since SR-B LIMP2-deficient mice show reduced expression of several apical plasma membrane proteins, sorting of proteins to the apical membrane is likely an evolutionarily conserved function of Dsb and LIMP2 (Wingen et al. 2017).

Accession Number:A8JNI3
Protein Name:Debris buster, isoform D
Length:615
Molecular Weight:69977.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLEKHYLRY GRTARDHLLD WATCGRGRRQ QQQQQQQQTH AQPSQGSTAT GRRSRPHVTH 
61:	RGTPLSMLIS NGVRISNNRL AVIIIGIITL ILGIILSSMP WLDYFILKNL RLWNDTLSYH 
121:	YWQRPGVIRL TKLYIYNVTN PDGFLRGEKP HLQEVGPFVY REDMQKVNVK FHENNYTVSY 
181:	QHKKILQFVP ELSIDKDTPI TTPNIPLLTL TSLSPKLGYL LSKTISVVVT AAQFKPFINV 
241:	TAEQLAFGYD DALVSLAHRF YPKHMRPMER MGLLLGRNGT LTEVSSVKTG MDSMDQFGYI 
301:	DQLNGLDHLP HWSEPPCTSI AGSEGSFFPP RELTKSEVVH IYDKDLCRII PLKYVESLEK 
361:	DGIAADLFRL PNNSYGDSAH NPENKCYDTS EYEPIQGLQN ISPCQYGAPV YISNPHFFES 
421:	HPDLLNSVEG LKPEREKHET YFKIQPKLGV PLEGKVRIQL NLKVTRAKDV YPVRDFRDFV 
481:	FPVMWLEEGI SELTPAIKRW IYLGTVIAPS AVPIGSYLMI LGGAFAIIFS FVRAYQNFMF 
541:	AQDPTLEILE MGRRSLRRGS SFIAHQQHRL LVHHRDSYSL LRHGPMATCL GEGNREEDAQ 
601:	PIIDVSLSGG ISQES