9.B.417.1.2
LMAN2 or VIP36 (GP36B, C5orf8) of 356 aas and 2 TMSs, N- and C-terminal. It plays a role as an intracellular lectin in the early secretory pathway and interacts with N-acetyl-D-galactosamine and high-mannose type glycans
as well as O-linked glycans. It is involved in the transport and
sorting of glycoproteins carrying high mannose-type glycans. LMAN2 expression had a positive link to breast cancer stemness, proliferation, metastasis, and differentiation (Zhang et al. 2022).It also regulates Kv1.2 (TC# 1.A.1.2.10) redox-sensitive gating (Lamothe et al. 2024).
|
| Accession Number: | Q12907 |
|---|
| Protein Name: | Vesicular integral-membrane protein VIP36 |
|---|
| Length: | 356 |
|---|
| Molecular Weight: | 40229.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 2 |
|---|
| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum-Golgi intermediate compartment membrane1 / Single-pass type I membrane protein2 |
|---|
| Substrate |
|
|---|
1: MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL
61: IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV
121: HGTGKKNLHG DGIALWYTRD RLVPGPVFGS KDNFHGLAIF LDTYPNDETT ERVFPYISVM
181: VNNGSLSYDH SKDGRWTELA GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI
241: DITGVRLPTG YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK
301: SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE RNKRFY