TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.418.1.1









Insulin-induced gene 2 protein, INSIG2, of 225 aas and 6 TMSs. It functions with SCAP (TC# 2.A.6.6.4) to control the  of enzymes and transport systems involved in the biosynthesis of cholesterol and other sterols (Yan et al. 2021). See family description for details.

Eukaryota
Metazoa, Chordata
Insig-2 of Homo sapiens
9.B.418.1.2









Insulin-induced gene 1 protein, INSIG1, of 277 aas and 6 or 7 TMSs. Like INSIG2, it binds oxysterols, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the ER (Xu et al. 2020). It also regulates degradation of SOAT2/ACAT2 when the lipid levels are low, and initiates the ubiquitin-mediated degradation of sterol O-acyltransferase 2 (SOAT2/ACAT2) (TC# 2.A.50.4.11) via recruitment of the ubiquitin ligases AMFR/gp78 (Wang et al. 2017). It resembles INSIG2 in many functional respects (see 9.B.418.1.1).

Eukaryota
Metazoa, Chordata
Insig-1 of Homo sapiens
9.B.418.1.3









Insulin-induced protein of 473 aas and 6 TMSs in a 1 + 1 + 4 (C-terminal) TMSs. It shows good sequence similarity to Insig-1 and -2 only in the 4 TMS C-terminal domain.

Eukaryota
Fungi, Ascomycota
Insulin-induced protein of Ascosphaera apis
9.B.418.1.4









Uncharacterized protein of 373 aas and 10 or 11 TMSs in a 4 or 5 + 6 TMS arrangement.  The last 6 TMSs are members of this family.

Bacteria
Planctomycetota
UP of Planctomycetes bacterium
9.B.418.1.5









Uncharacterized protein of 185 aas and 6 TMSs.

Bacteria
Myxococcota
UP of Hyalangium minutum
9.B.418.1.6









Uncharacterized protein of 213 aas and 6 TMSs.

Bacteria
Actinomycetota
UP of Mycobacteroides salmoniphilum
9.B.418.1.7









Multidomain LON peptidase N-terminal domain and RING finger protein 1of 848 aas and about 7 TMSs in a 1 + 1 + 3 + 1 + 1 TMS arrangement.  TMSs 2 - 6 are homologous to other members of this family.

Eukaryota
Fungi, Ascomycota
Multidomain protein of Ophiocordyceps camponoti-floridani