9.B.418.1.2
Insulin-induced gene 1 protein, INSIG1, of 277 aas and 6 or 7 TMSs. Like INSIG2, it binds oxysterols, including 25-hydroxycholesterol,
regulating interaction with SCAP and retention of the SCAP-SREBP complex
in the ER (Xu et al. 2020). It also regulates degradation of SOAT2/ACAT2 when the
lipid levels are low, and initiates the ubiquitin-mediated degradation of sterol O-acyltransferase 2 (SOAT2/ACAT2) (TC# 2.A.50.4.11) via recruitment of the ubiquitin ligases AMFR/gp78 (Wang et al. 2017). It resembles INSIG2 in many functional respects (see 9.B.418.1.1).
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| Accession Number: | O15503 |
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| Protein Name: | Insulin-induced gene 1 protein |
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| Length: | 277 |
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| Molecular Weight: | 29987.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP
61: RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA
121: TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK
181: LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD
241: FLYIRSWLPC IFFSGGVTVG NIGRQLAMGV PEKPHSD