| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.422.1.1 | Transmembrane protein TMEM26 of 368 aas and possibly 9 or 12 TMSs in a possible 3 + 3 + 3 or (less likely) 3 + 3 + 3 + 3 TMS arrangement. Members of this family play roles in beige adipocyte formation in overweight animals (Rachid et al. 2018), and may target obesity by influencing fat oxidation and thermogenesis (Liu et al. 2019). Its gene expression is influenced by emodin (Cheng et al. 2021) and activated by flavan-3-ols (Ishii et al. 2021). | Eukaryota |
Metazoa, Chordata | TMEM26 of Homo sapiens |
|
9.B.422.1.2 | Uncharacterized protein of 385 aas and 9 TMSs in a 3 + 3 + 3 TMS arrangement. | Eukaryota |
Metazoa, Rotifera | UP of Adineta ricciae |
|
9.B.422.1.3 | Uncharacterized protein of 452 aas and possibly 6 or 9 TMSs in a 3 + 3 or 3 + 3 + 3 TMS arrangement. | Eukaryota |
Metazoa, Cnidaria | UP of Orbicella faveolata |
|
9.B.422.1.4 | TMEM26 of 505 aas and 4 C-terminal TMSs, which is where there is sequence similarity with other members of the family. Clonorchis sinensis (family Opisthorchiidae) is an important foodborne parasite that has a major socioeconomic impact on ~35 million people predominantly in China, Vietnam, Korea and the Russian Far East. In humans, infection with C. sinensis causes clonorchiasis, a complex hepatobiliary disease that can induce cholangiocarcinoma, a malignant cancer of the bile ducts (Wang et al. 2018). | Eukaryota |
Metazoa, Platyhelminthes | TMEM26 of Clonorchis sinensis |
|
9.B.422.1.5 | Uncharacterized protein of 291 aas and 6 TMSs, 3 N-terminal and 3 C-terminal with a large central hydrophilic region. | Eukaryota |
Metazoa, Platyhelminthes | UP of Dibothriocephalus latus |
|
9.B.422.1.6 | Uncharacterized protein of 364 aas and 7 - 9 TMSs in a possible 2 + 3 + 3 TMS arrangement. | Eukaryota |
Metazoa, Rotifera | UP of Adineta ricciae |
|
9.B.422.1.7 | Uncharacterized protein of 642 aas and 6 TMSs, 3 N-terminal and 3 C-terminal, separated by a large hydrophilic loop. | Eukaryota |
Metazoa, Cnidaria | UP of Nematostella vectensis (starlet sea anemone) |
|
9.B.422.1.8 | Uncharacterized protein of 358 aas and 5 TMSs in a 3 + 2 TMS arrangement. This proteins shows some similarity to members of TC# 1.A.82. | Eukaryota |
Metazoa, Cnidaria | UP of Nematostella vectensis (starlet sea anemone) |
|
9.B.422.1.9 | Uncharacterized protein of 316 aas and 7 TMSs in a possible 2 + 5 TMS arrangement. | Eukaryota |
Metazoa, Rotifera | UP of Rotaria sordida |
|
9.B.422.1.10 | TMEM26 isoform X1, of 477 aas and ~ 9 - 10 TMSs in a 3 + 6 or 7 TMS arrangement. | Eukaryota |
Metazoa, Mollusca | TMEM26 of Mizuhopecten yessoensis |
|
9.B.422.1.11 | Uncharacterized protein of 314 aas and 8 or 9 TMSs in a 3 + 3 + 2 or 3 TMS arrangement. | Eukaryota |
Metazoa, Annelida | UP of Helobdella robusta |