9.B.422.1.1
Transmembrane protein TMEM26 of 368 aas and possibly 9 or 12 TMSs in a possible 3 + 3 + 3 or (less likely) 3 + 3 + 3 + 3 TMS arrangement. Members of this family play roles in beige adipocyte formation in overweight animals (Rachid et al. 2018), and may target obesity by influencing fat oxidation and thermogenesis (Liu et al. 2019). Its gene expression is influenced by emodin (Cheng et al. 2021) and activated by flavan-3-ols (Ishii et al. 2021).
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| Accession Number: | Q6ZUK4 |
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| Protein Name: | Transmembrane protein 26 |
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| Length: | 368 |
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| Molecular Weight: | 41672.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEGLVFLNAL ATRLLFLLHS LVGVWRVTEV KKEPRYWLLA LLNLLLFLET ALTLKFKRGR
61: GYKWFSPAIF LYLISIVPSL WLLELHHETQ YCSIQAEGTS QNTSRKEDFN QTLTSNEQTS
121: RADDLIETAK VFVNNLSTVC EKVWTLGLHQ TFLLMLIIGR WLLPIGGGIT RDQLSQLLLM
181: FVGTAADILE FTSETLEEQN VRNSPALVYA ILVIWTWSML QFPLDLAVQN VVCPVSVTER
241: GFPSLFFCQY SADLWNIGIS VFIQDGPFLV VRLILMTYFK VINQMLVFFA AKNFLVVVLQ
301: LYRLVVLALA VRASLRSQSE GLKGEHGCRA QTSESGPSQR DWQNESKEGL AIPLRGSPVT
361: SDDSHHTP