TCDB is operated by the Saier Lab Bioinformatics Group

9.B.425.  The Uncharacterized 12 TMS Transmembrane Protein (U12TP) Family

The protein members of this family are derived from a diversity of bacteria. One of them (TC# 9.B.425.1.1) has about 900 aas and 11 or 12 TMSs in its N-terminal half with a large (~400 hydrophilic C-terminal domain. It may belong to the DUF998 domain-containing protein family. Another member of the family (TC# 9.B.425.1.2) has just the hydrophobic domain. Some bacteria have a ~300 aa residue protein that corresponds to the last 300 residues of 9.B.425.1.1 and may have one TMS.