9.B.445.2.1
Apolipoprotein E, APOE, of 317 aas and 1 TMS.  APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (Krimbou et al. 2004).  It is a core component of plasma lipoproteins and is involved in their production, conversion and clearance, and influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association under physiological conditions (Verghese et al. 2013). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and it thereby plays an important role in cholesterol homeostasis (Connolly et al. 2023).