| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.445.1.1 | ApoLipoprotein E2 (ApoEII, ApoLP EII) of 100 aas with 1 N-terminal TMS, and possibly one C-terminal TMS. Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling (Wang et al. 2022). It may stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect HDL metabolism. | Eukaryota |
Metazoa, Chordata | ApoLP EII of Homo sapiens |
|
9.B.445.1.2 | ApoLP AII of 100 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | ApoLP AII of Zootoca vivipara (common lizard) |
|
9.B.445.1.3 | Type-4 ice-structuring protein-like of 129 aas and one N-terminal TMS (Di Natale et al. 2019). | Eukaryota |
Metazoa, Chordata | Ice-structuring protein of Pygocentrus nattereri (red-bellied piranha) |
|
9.B.445.1.4 | Apolipoprotein A-II-like protein of 99 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | ApoLP AII of Sphaerodactylus townsendi |
|
9.B.445.1.5 | Embryogenesis regulator of 130 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | Embryogenesis regulator of Carassius gibelio (silver crucian carp) |
|
9.B.445.1.6 | Antifreeze protein type IV of 154 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | Antifreeze protein of Epinephelus fuscoguttatus (brown-marbled grouper) |
|
9.B.445.1.7 | Type-4 ice-structuring protein LS-12-like of 126 aas and 1 N-terminal TMS, possibly with a second TMS at the C-terminus of the protein. | Eukaryota |
Metazoa, Chordata | LS-12-like protein of Myxocyprinus asiaticus (Chinese sucker) |
|
9.B.445.2.1 | Apolipoprotein E, APOE, of 317 aas and 1 TMS. APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (Krimbou et al. 2004). It is a core component of plasma lipoproteins and is involved in their production, conversion and clearance, and influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association under physiological conditions (Verghese et al. 2013). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and it thereby plays an important role in cholesterol homeostasis (Connolly et al. 2023). | Eukaryota |
Metazoa, Chordata | APOE of Homo sapiens |
|
9.B.445.2.2 | Apolipoprotein A-IV, APOA4, of 458 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | APOAIV of Carlito syrichta (Philippine tarsier) |
|
9.B.445.2.3 | Uncharacterized protein of 458 aas and 1 - 3 N-terminal TMSs. | Eukaryota |
Metazoa, Chordata | UP of Coryphaenoides rupestris (roundnose grenadier) |
|
9.B.445.2.4 | Uncharacterized protein of 378 aas with a large peak of hydrophobicity at ~ residue 180 and an apparent internal duplication. | Eukaryota |
Metazoa, Chordata | UP of Caranx melampygus (bluefin trevally) |
|
9.B.445.2.5 | Apolipoprotein A-I isoform X1 of 273 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | APOAI isoform X1 of Xenopus tropicalis |