TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.445.1.1









ApoLipoprotein E2 (ApoEII, ApoLP EII) of 100 aas with 1 N-terminal TMS, and possibly one C-terminal TMS. Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling (Wang et al. 2022). It may stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect HDL metabolism.

Eukaryota
Metazoa, Chordata
ApoLP EII of Homo sapiens
9.B.445.1.2









ApoLP AII of 100 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
ApoLP AII of Zootoca vivipara (common lizard)
9.B.445.1.3









Type-4 ice-structuring protein-like of 129 aas and one N-terminal TMS (Di Natale et al. 2019).

Eukaryota
Metazoa, Chordata
Ice-structuring protein of Pygocentrus nattereri (red-bellied piranha)
9.B.445.1.4









Apolipoprotein A-II-like protein of 99 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
ApoLP AII of Sphaerodactylus townsendi
9.B.445.1.5









Embryogenesis regulator of 130 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
Embryogenesis regulator of Carassius gibelio (silver crucian carp)
9.B.445.1.6









Antifreeze protein type IV of 154 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
Antifreeze protein of Epinephelus fuscoguttatus (brown-marbled grouper)
9.B.445.1.7









Type-4 ice-structuring protein LS-12-like of 126 aas and 1 N-terminal TMS, possibly with a second TMS at the C-terminus of the protein.

Eukaryota
Metazoa, Chordata
LS-12-like protein of Myxocyprinus asiaticus (Chinese sucker)
9.B.445.2.1









Apolipoprotein E, APOE, of 317 aas and 1 TMS.  APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (Krimbou et al. 2004).  It is a core component of plasma lipoproteins and is involved in their production, conversion and clearance, and influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association under physiological conditions (Verghese et al. 2013). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and it thereby plays an important role in cholesterol homeostasis (Connolly et al. 2023).

Eukaryota
Metazoa, Chordata
APOE of Homo sapiens
9.B.445.2.2









Apolipoprotein A-IV, APOA4, of 458 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
APOAIV of Carlito syrichta (Philippine tarsier)
9.B.445.2.3









Uncharacterized protein of 458 aas and 1 - 3 N-terminal TMSs.

Eukaryota
Metazoa, Chordata
UP of Coryphaenoides rupestris (roundnose grenadier)
9.B.445.2.4









Uncharacterized protein of 378 aas with a large peak of hydrophobicity at ~ residue 180 and an apparent internal duplication.

Eukaryota
Metazoa, Chordata
UP of Caranx melampygus (bluefin trevally)
9.B.445.2.5









Apolipoprotein A-I isoform X1 of 273 aas and 1 N-terminal TMS.

Eukaryota
Metazoa, Chordata
APOAI isoform X1 of Xenopus tropicalis