9.B.451. The Parasitophorous Vacuole Membrane Protein (Pfs16) Family
It is involved in male gametogenesis and is required for exflagellation of male gametocytes. It may play a role in parasite transmission in the mosquito and binds to the mosquito vector midgut (Niu et al. 2021). Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity (Ramelow et al. 2023). Antibodies against Pfs16 partially reduce parasite transmission during the mosquito vector stage, resulting in a significant reduction in the number of oocysts.
References associated with 9.B.451 family:
Niu, G., Y. Cui, X. Wang, Y. Keleta, and J. Li. (2021). Studies of the Parasite-Midgut Interaction Reveal Proteins Important for Malaria Transmission to Mosquitoes. Front Cell Infect Microbiol 11: 654216. 34262880
Ramelow, J., Y. Keleta, G. Niu, X. Wang, and J. Li. (2023). Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity. J. Biol. Chem. 104824. [Epub: Ahead of Print] 37196765