9.B.468. The Hfq RNA Chaparone Protein (Hfq) Family
In addition to being a chaparone protein for sRNA, tRNA and mRNA, it seems to play roles in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation (Kim and Wood 2010) and in drug resistance in bacteria (Bloch et al. 2025).
References associated with 9.B.468 family:
Bloch, S., G. Węgrzyn, and V. Arluison. (2025). The Role of the Hfq Protein in Bacterial Resistance to Antibiotics: A Narrative Review. Microorganisms 13:. 40005731
Kim, Y. and T.K. Wood. (2010). Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochem. Biophys. Res. Commun. 391: 209-213. 19909729
Turbant, F., N. Lewandowska, S. Bloch, F. Wien, H. Chauvet, G. Węgrzyn, and V. Arluison. (2025). Hfq influences ciprofloxacin accumulation in Escherichia coli independently of ompC and ompF post-transcriptional regulation. J Appl Genet 66: 449-457. 39920540