9.B.468.1.1 The Hfq RNA chaparone protein of 102 aas. It influences persistence formation in bacteria and multidrug resistance (Bloch et al. 2025). Since fluoroquinolones use both protein- and lipid-mediated pathways to
cross the outer membrane, Hfq probably influences both processes as its absence causes more effective accumulation of the antibiotic ciprofloxacin in
Escherichia coli cells, irrespective of the presence or absence of the
AcrB efflux pump (Turbant et al. 2025).
|
Accession Number: | P0A6X3 |
Protein Name: | RNA-binding protein Hfq |
Length: | 102 |
Molecular Weight: | 11166.00 |
Species: | Escherichia coli (strain K12) [83333] |
Substrate |
(ribonucleotide)n+m |
---|
1: MAKGQSLQDP FLNALRRERV PVSIYLVNGI KLQGQIESFD QFVILLKNTV SQMVYKHAIS
61: TVVPSRPVSH HSNNAGGGTS SNYHHGSSAQ NTSAQQDSEE TE