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9.B.68 The Putative Na-independent Organic Solute Carrier Protein (OSCP1) Family

Kobayashi et al. (2005) reported the isolation of a novel organic solute carrier from a human placenta cDNA library. The 379 aas protein has an N-terminal hydrophobic peak but otherwise appears hydrophilic. When expressed in Xenopus laevis oocytes, high-affinity transport of PAH and TEA was observed. Because of its hydrophilic nature, it seems possible that it stimulated uptake via endogenous frog transporters.


References associated with 9.B.68 family:

Kobayashi, Y., A. Shibusawa, H. Saito, N. Ohshiro, M. Ohbayashi, N. Kohyama, and T. Yamamoto. (2005). Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. J. Biol. Chem. 280: 32332-32339. 16006562