9.B.68.1.1
The putative Na+-independent organic solute transporter (takes up or stimulates uptake of p-amino hippurate (PAH) (Km = 35.0 µM), tetraethylammonium (Km = 62 µM) and other organic solutes in frog oocytes). The protein exhibits one N-terminal TMS but is otherwise hydrophilic (Kobayashi et al., 2005).
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| Accession Number: | Q8WVF1 |
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| Protein Name: | OSCP1 |
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| Length: | 379 |
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| Molecular Weight: | 43271.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Basal cell membrane1 |
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| Substrate |
tetraethylammonium, p-aminohippuric acid |
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| RefSeq: |
NP_659484.4
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| Entrez Gene ID: |
127700
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| Pfam: |
PF10188
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| OMIM: |
608854 gene
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| KEGG: |
hsa:127700
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[1] “Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE-1 nasopharyngeal carcinoma cell line.” Nie X. et.al. 12819961
[2] “Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.” Kobayashi Y. et.al. 16006562
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T. et.al. 14702039
[4] “The DNA sequence and biological annotation of human chromosome 1.” Gregory S.G. et.al. 16710414
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
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1: MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKVLN DIISTMFNRK FMEELFKPQE
61: LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD
121: TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH IRVSMFLKDK
181: VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA PKEGSFELYG
241: DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA RLMGGMEIKK
301: PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA RIMGEFEITE
361: QPRLSTSKGD DLLAMMDEL