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1.B.14.2.4
Lactoferrin receptor (A=OMR porin; B=lipoprotein), LbpAB or IroAB. This two-component system extracts iron from the host glycoproteins lactoferrin and transferrin. Homologous iron-transport systems consist of a membrane-bound transporter and an accessory lipoprotein. The crystal structure of the N-terminal domain (N-lobe) of the accessory lipoprotein, lactoferrin-binding protein B (LbpB) is homologous to the structures of the accessory lipoproteins, transferrin-binding protein B (TbpB) and LbpB from the bovine pathogen Moraxella bovis. Docking the LbpB  with lactoferrin reveals extensive binding interactions with the N1 subdomain of lactoferrin. The nature of the interaction precludes apolactoferrin from binding LbpB, ensuring the specificity for iron-loaded lactoferrin, safeguarding proper delivery of iron-bound lactoferrin to the transporter LbpA. The structure also reveals a possible secondary role for LbpB in protecting the bacteria from host defences. Following proteolytic digestion of lactoferrin, a cationic peptide derived from the N-terminus is released. This peptide, called lactoferricin, exhibits potent antimicrobial effects. The docked model of LbpB with lactoferrin reveals that LbpB interacts extensively with the N-terminal lactoferricin region (Brooks et al. 2014). 

Accession Number:O87343
Protein Name:LbpA
Length:943
Molecular Weight:105427.00
Species:Neisseria meningitidis [487]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate

Cross database links:

Pfam: PF07715    PF00593   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Identification and molecular analysis of lbpBA, which encodes the two-component meningococcal lactoferrin receptor.”  Lewis L.A.et.al.   9596785

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FASTA formatted sequence
1:	MNKKHGFQLT LTALAVAAAF PSYAANPETA APDAAQTQSL KEVTVRAAKV GRRSKEATGL 
61:	GKIVKTSETL NKEQVLGIRD LTRYDPGVAV VEQGNGASGG YSIRGVDKNR VAVSVDGVAQ 
121:	IQAFTVQGSL SGYGGRGGSG AINEIEYENI STVEIDKGAG SSDHGSGALG GAVAFRTKEA 
181:	ADLISDGKSW GIQAKTAYGS KNRQFMKSLG AGFSKDGWEG LLIRTERQGR ETHPHGDIAD 
241:	GVAYGINRLD AFRQTYGIKK PSEGGEYFLA EGESELKPVA KVAGNGNYLN NQLNRWVKER 
301:	IEQNQPLSAE EEAMVREAQA RHENLSAQAY TGGGRILPDP MDYRSGSWLA KLGYRFGGRH 
361:	YVGGVFEDTK QRYDIRDMTE KQYYGTDEAK KFRDKSGVYD GDDFRDGLYF VPNIEEWKGD 
421:	QKLIRGIGLK YSRTKFIDEH HRRRRMGLLY RYENEKYSDN WADKAVLSFD KQGVATDNNT 
481:	LKLNCAVYPA VDKSCRASAD KPYSYDSSDR FHYREQHNVL NASFEKSLKN KWTKHHLTLG 
541:	FGYDASNAIS RPEQLSHNAA RISEYSDYTD KGDKYLLGKP EVVEGSVCGY IETLRSRKCV 
601:	PRKINGSNIH ISLNDRFSIG KYFDFSSGGR YDRKNFTTSE ELVRSGRYVD RSWNSGIVFK 
661:	PNRHFSLSYR ASSGFRTPSF QELFGIDIYH DYPKGWQRPA LKSEKAANRE IGLQWKGDFG 
721:	FLEISSFRNR YTDMIAVADH KTKLPNQAGQ LTEIDIRDYY NAQNMSLQGV NILGKIDWNG 
781:	VYGKLPEGLY TTLAYNRIKP KSVSNRPGLS LRSYALDAVQ PSRYVLGFGY DQPEGKWGAN 
841:	IMLTYSKGKN PDELAYLAGD QKRYSTKRAS SSWSTADVSA YLNLKKRLTL RAAIYNIGNY 
901:	RYVTWESLRQ TAESTANRHG GDSNYGRYAA PGRNFSLALE MKF