1.A.1.11.18
The nicotinic acid adenine dinucleotide phosphate (NAADP)- dependent two pore Ca2+- channel, TPC3 (Brailoiu et al., 2010). Phosphoinositides regulate dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3 (Hirazawa et al. 2021). Each TPC subunit contains 12 TMSs that can be divided into two homologous
copies of an S1-S6 Shaker-like 6-TMS domain. A functional TPC channel
assembles as a dimer. The plant TPC channel is localized in the vacuolar
membrane and is also called the SV channel for generating the slow
vacuolar (SV) current. Three subfamilies of mammalian TPC channels have
been defined - TPC1, 2, and 3 - with the first two being ubiquitously
expressed in animals and TPC3 being expressed in some animals, but not
in humans. Mammalian TPC1 and TPC2 are localized to endolysosomal
membranes (She et al. 2022).
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| Accession Number: | C4IXV8 |
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| Protein Name: | Two pore channel 3 |
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| Length: | 768 |
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| Molecular Weight: | 88011.00 |
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| Species: | Bos taurus (Bovine) [9913] |
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| Number of TMSs: | 12 |
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| Substrate |
potassium(1+) |
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1: MPGNSRAAGT HHSRPSSSEE PPDLEDQELL LAAAYVSDAQ YNRNVPFETS PQAIRLYHFY
61: NHWTMRAATY FFIWVNLALA LFEEPAVFPL PFLVTSIAEV LCLTAFFGRL VHFAKVTPQK
121: VFWKDTKNIC VMVTIVLTLI DLVIYGSLEA VNIRGVRWSR ALRPVFLINF PESRQIRRTF
181: RSIRNTLPDI LYVFLLFLFS MMIFSLMALK LFGDRDLRTV EGSPYFTNIL DIAFELYVLV
241: TTANSPDVMM PAYELNWWYS LYFITYIIIN TYIFMSVFLA VIYNNYRKHL KNEIHTLAYL
301: KHHKMTEAFN ILKVKVGTEF VVKEARWRRL VKVVAPDVSS SHLELLLRIS DEGQKGHVDK
361: VNFLRLADLL NIRVVAINIK KHPLETWMPR VYQSSTSLLV QKMVQHRIFV WVYDVIILIN
421: AIFIALDEKD SLISYAEWLF LSLYIIEILL KLYTYEPSAY FGRKQFWNWF DTLIIIAALL
481: ATVANTTIQA RKYNSQQVLD IVLILRILRL LRVIVSIQRF RVIVTTLINI GPTMLTFGGL
541: VLVVYYAFAI IGMEVFHGKI HFLDPGSGSP DALVCGNPAL KDSAFAQGRY CKNNFNDLAS
601: SLILLTELTV VNQWHILADG FALVTHQAAK LYFIGFHVVV VILIVNIFIA FILEAFFVAY
661: SLEKSEVETA IEKKIQELGV GVQEEEVQDG GLIDNMDAKD SGFSPDEGDN KKKDLKGLYF
721: RIASKKYKTV DTLLQQMFES EIAPEGKDPS LKEILSFSPK KVNFDNSA