1.A.1.11.18 The nicotinic acid adenine dinucleotide phosphate (NAADP)- dependent two pore Ca2+- channel, TPC3 (Brailoiu et al., 2010). Phosphoinositides regulate dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3 (Hirazawa et al. 2021).
|
Accession Number: | C4IXV8 |
Protein Name: | Two pore channel 3 |
Length: | 768 |
Molecular Weight: | 88011.00 |
Species: | Bos taurus (Bovine) [9913] |
Number of TMSs: | 12 |
Substrate |
|
---|
1: MPGNSRAAGT HHSRPSSSEE PPDLEDQELL LAAAYVSDAQ YNRNVPFETS PQAIRLYHFY
61: NHWTMRAATY FFIWVNLALA LFEEPAVFPL PFLVTSIAEV LCLTAFFGRL VHFAKVTPQK
121: VFWKDTKNIC VMVTIVLTLI DLVIYGSLEA VNIRGVRWSR ALRPVFLINF PESRQIRRTF
181: RSIRNTLPDI LYVFLLFLFS MMIFSLMALK LFGDRDLRTV EGSPYFTNIL DIAFELYVLV
241: TTANSPDVMM PAYELNWWYS LYFITYIIIN TYIFMSVFLA VIYNNYRKHL KNEIHTLAYL
301: KHHKMTEAFN ILKVKVGTEF VVKEARWRRL VKVVAPDVSS SHLELLLRIS DEGQKGHVDK
361: VNFLRLADLL NIRVVAINIK KHPLETWMPR VYQSSTSLLV QKMVQHRIFV WVYDVIILIN
421: AIFIALDEKD SLISYAEWLF LSLYIIEILL KLYTYEPSAY FGRKQFWNWF DTLIIIAALL
481: ATVANTTIQA RKYNSQQVLD IVLILRILRL LRVIVSIQRF RVIVTTLINI GPTMLTFGGL
541: VLVVYYAFAI IGMEVFHGKI HFLDPGSGSP DALVCGNPAL KDSAFAQGRY CKNNFNDLAS
601: SLILLTELTV VNQWHILADG FALVTHQAAK LYFIGFHVVV VILIVNIFIA FILEAFFVAY
661: SLEKSEVETA IEKKIQELGV GVQEEEVQDG GLIDNMDAKD SGFSPDEGDN KKKDLKGLYF
721: RIASKKYKTV DTLLQQMFES EIAPEGKDPS LKEILSFSPK KVNFDNSA