1.A.1.3.8
SLOwpoke K+ channel, SLO-2 or Slo2, of 1107 aas and 6 TMSs, present in motor neurons. It has six putative TMSs with a K+-selective pore and a large C-terminal cytosolic domain (Lim et al. 1999). Its requirements for both Cl- and Ca2+ are synergistic and associated with the same functional domain (Yuan et al. 2000) which serves to counteract hypoxia stress when cytoplasmic Cl- and Ca2+ concentrations increase (Yuan et al. 2003; Santi et al. 2003). SLO2 protects from hypoxic injury by increasing the permeability of the mitochondrial inner membrane to K+ (Wojtovich et al. 2011). SLO-2 is functionally coupled with CaV1 and regulates neurotransmitter release (Liu et al. 2014). Partially responsible for action potential repolarization during synaptic transmission (Ford and Davis 2014).
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| Accession Number: | G5EDJ1 |
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| Protein Name: | SLO-2 potassium channel |
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| Length: | 1107 |
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| Molecular Weight: | 127393.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 4 |
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| Substrate |
potassium(1+) |
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1: MSDDTNNRTD RCTMKHRERR VDSCHSLPSD YRIPNKHVAR MQYGEKKNIK HKLQQWFIEN
61: PSISARIRSC NVLIKLLTCI LYCIRVVNDE RSYPDDFPFS EEEAGKQDVT LYKYLLWVDF
121: DFKIWFLQTM FACISMVYTI LVFYLSYSGS VVRLLINIHF LLELITSFPF IISIFIPSLT
181: YLYVPVFLNC WLAKGALQAM MNDLNRKSFI SSSALFRQLL LLFSVLACLI FTGMCSIEHL
241: QRARGKRIDL FTSFYFVMVT FSTVGYGDWY PDYWASQLCV VILICVALGL IPKQLDELGQ
301: TWSERQKSGT DFSSWNGVES HVVVTITTLE VEFIRDFLEE FYAHPENQRI QIVLLSPAEL
361: DNQTRMLLKI PLWNNRVHYV RGSSLRDEDL ERANVATSKA CFILSARHVN RKVATDEHTI
421: LRSWAIKDFA PNVKQYVQIF RAETKMHIEH AEVLICEDEF KYALLANNCI CPGISTFITL
481: LMHTSRGEEG QKSTEPWHKV YGFHSGNEMY QIKVQDSKFF CEYVGKSFSS TSFHAHKEYG
541: IGLIAVSPDG DTSRMKLNPG SSHIIQPTDT VYYMGLTNEE SLTDFRKGIR SQQKRANVAS
601: TIANIGTVAV DVPRSDKTEL VGRKKKKRKE KAADEIHLIE VGEHVQSSRR PSIAMVTEGK
661: IDSSSDSDQE EICDKCRGPC IQHKLQRTYP QVRTYIGTSN TVCHMMKERR SLCCLKLDEK
721: CAHKSATSAH EYQWRNRPII LAADRTSSGM YNLVIPLRAY YRPVHDLHPI IILLELEEQD
781: SLNDAFLDAI SYFPDVYWMK GKVGNLDCLL RAGVSSAEHV VVVKETAVMA EEHTADCNTI
841: ITVQKIHRMF PRLRMITELT HATNMRFVQF NPHNAYSLAQ SRFEKKERKR GSHMPFMFRL
901: PFAQGGVFSA NMLDRLLYQA IIKPFVVDLV RLLLGIDQHS DGGYLTSFVI TSDDLWIRNY
961: GRLYQKLCSS VADIPIGIFR TKKMDTKTVS LDLQEQCKDF ENTEMGRNKD MYDHVKNRMR
1021: LLNIKDTHTL LEGSDEKSQI SYVIINPAQD LELESGDIVY VIRSPIRKDA TNARINPRRG
1081: LRRSKNVSET IDSTNQVPTI VIDENNL