1.A.1.5.31
Multi-domain cation channel with a C-terminal cyclic nucleotide-binding domain; of 465 aas and 6 TMS, LliK. Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-regulated (HCN) channels play roles in phototransduction, olfaction, and cardiac pace making. James et al. 2017 used cryoEM to determine the structure of the intact LliK CNG channel. A short S4-S5 linker connects voltage-sensing and pore domains to produce a non-domain-swapped transmembrane architecture. The conformation of the LliK structure may represent a functional state of this channel family not seen before (James et al. 2017).
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| Accession Number: | I0XVQ9 |
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| Protein Name: | Transporter, cation channel family / cyclic nucleotide-binding domain multi-domain protein |
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| Length: | 434 |
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| Molecular Weight: | 49854.00 |
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| Species: | Leptospira licerasiae serovar Varillal str. VAR 010 [1049972] |
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| Number of TMSs: | 6 |
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| Substrate |
inorganic cation, potassium(1+) |
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1: MITLKNRIRV YWDILVFICI FWASLESPLR IVINYDPNLL LTCIYFFIDF VFALDILWNC
61: FTPEYKDGKW ILTRSQVIKD YLGSWFIIDL IAALPLEYAT TTIFGLQQSQ YPYLYLLLGV
121: TRILKVFRIS DILQRINLAF QPTPGILRLV LFAFWATLVA HWCAVGWLYV DDLLDYQTGW
181: SEYIIALYWT VATIATVGYG DITPSTDSQR IYTIFVMILG AGVYATVIGN IASILGSLDL
241: AKAAQRKKMA QVDSFLKARN ISQNIRRRVR DYYMYIIDRG WGEDENALLN DLPISLRREV
301: KIQLHRDLLE KVPFLKGADP ALVTSLVFSM KPMIFLEGDT IFRRGEKGDD LYILSEGSVD
361: ILDSDEKTIL LSLQEGQFFG ELALVMDAPR SATVRATTTC EIYTLSKTDF DNVLKRFSQF
421: RSAIEESVAH LKKR