TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.A.120.1.1 | The coronaviral double membrane-spanning pore complex in the replication organelle (RO) of the viral double membrane vesicle (DMV). The pore consists of a hexameric complex. The primary constituent of each of the six subunits of the pore is the non-structural protein-3, nsp3, of 2309 aas, which may have 5 TMSs, based on a hydrophathy plot of the protein. These are clustered together about two-thrids of the way towards the C-terminus. It is the core constituent of the pore and has both its N-terminal domain of 160 kDa and a smaller C-terminal domain, which contains a ubiquitin domain (Ubi1) of 12.6 kDa, that together form the prongs of the cytoplasmic crown. nsp3 interacts with nsp4, and this complex is believed to drive membrane pairing and participate in DMV biogenesis (Wolff et al. 2020). It may associate with other viral and host proteins. | Viruses |
Orthornavirae, Pisuviricota | nsp3-nsp4 of murine hepatitis virus |
1.A.120.1.2 | Polyprotein 1a of 4018 aas and ~ 10 TMSs. | Viruses |
Orthornavirae, Pisuviricota | PP 1a of Canine coronavirus |
1.A.120.1.3 | ORF1a polyprotein, partial of 4345 aas and ~ 7 TMSs. A cell-based system combined with flow cytometry has been used to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19 (Martin et al. 2022). | Viruses |
Orthornavirae, Pisuviricota | ORF1a polyprotein of Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 |
1.A.120.1.4 | Non structural protein 6 (Nsp6) of 290 aas and 7 - 9 TMSs. If 7 TMSs, they occur in a 3 + 1 + 3 TMS arrangement. If 8 TMSs, they occur in a 3 + 5 TMS arrangement. If 9 TMSs, they are all closely adjacent to each other. Nsp6 is part of the large polyprotein 1a of this virus. | Viruses |
Orthornavirae, Pisuviricota | Nsp6 of severe acute respiratory syndrome coronavirus 2 |
1.A.120.1.5 | Polyprotein 1a, partial, of 220 aas and 6 or 7 TMSs | Viruses |
Orthornavirae, Pisuviricota | PP1a of Porcine deltacoronavirus |
1.A.120.1.6 | Coronavirus Nsp3 (HD2) of 293 aas and 7 TMSs | Viruses |
Orthornavirae, Pisuviricota | Nsp3 of Infectious bronchitis virus |