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1.A.14.3.10
The Protein Lifeguard 3 (LFG3, RECS1, Tmbim1) of 311 aas and 7 TMSs. LFG3 is a multivesicular bidy regulator that protects agains non-alcoholic fatty liver by targeting the lysosomal degradation of Tlr4 (Zhao et al. 2017). TMBIM1 protects against pathological cardiac hypertrophy through promoting the lysosomal degradation of activated TLR4 (Deng et al. 2018).

Accession Number:Q969X1
Protein Name:Protein lifeguard 3
Length:311
Molecular Weight:34607.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP AGYPQPMPPT 
61:	HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR KVYSIISVQL LITVAIIAIF 
121:	TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI LACCQGPRRR FPWNIILLTL FTFAMGFMTG 
181:	TISSMYQTKA VIIAMIITAV VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV 
241:	LYFQYVYWLH MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF 
301:	TFVLQLMGDR N