1.A.14.3.10
The Protein Lifeguard 3 (LFG3, RECS1, Tmbim1) of 311 aas and 7 TMSs. LFG3 is a multivesicular body regulator that protects against non-alcoholic fatty liver by targeting the lysosomal degradation of Tlr4 (Zhao et al. 2017). It also protects against pathological cardiac hypertrophy by promoting the lysosomal degradation of activated TLR4 (Deng et al. 2018). RECS1 is a pH-regulated calcium channel, an activity that is essential to trigger cell death (Pihán et al. 2021).
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| Accession Number: | Q969X1 |
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| Protein Name: | Protein lifeguard 3 |
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| Length: | 311 |
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| Molecular Weight: | 34607.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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1: MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP AGYPQPMPPT
61: HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR KVYSIISVQL LITVAIIAIF
121: TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI LACCQGPRRR FPWNIILLTL FTFAMGFMTG
181: TISSMYQTKA VIIAMIITAV VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV
241: LYFQYVYWLH MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF
301: TFVLQLMGDR N