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1.A.14.3.6
Protein lifeguard 4 (LFG4), also called Golgi anti-apoptotic protein (GAAP), Protein S1R, CGI-119, Transmembrane BAX inhibitor motif-containing protein 4, (TMBIM4) and Z-protein.  Forms cation-selective ion channels. Residues that contribute to the ion-conducting pore and affect apoptosis, cell adhesion and migration independently of each other have been identified (Carrara et al. 2015).  It's functions have been reviewed (Carrara et al. 2017). The N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1 (Hearn et al. 2023).

Accession Number:Q9HC24
Protein Name:Protein lifeguard 4
Length:238
Molecular Weight:26971.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ion, inorganic cation

Cross database links:

Entrez Gene ID: 51643   
Pfam: PF01027   
KEGG: hsa:51643   

Gene Ontology

GO:0005795 C:Golgi stack
GO:0016021 C:integral to membrane
GO:0006916 P:anti-apoptosis
GO:0006915 P:apoptotic process
GO:0050848 P:regulation of calcium-mediated signaling

References (8)

[1] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.”  Lai C.-H.et.al.   10810093
[2] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”  Hu R.-M.et.al.   10931946
[3] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[4] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “A new inhibitor of apoptosis from vaccinia virus and eukaryotes.”  Gubser C.et.al.   17319741
[7] “LFG: a candidate apoptosis regulatory gene family.”  Hu L.et.al.   19784873
[8] “Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.”  de Mattia F.et.al.   19553469

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT VTSTVFLYFE 
61:	SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL LFGFTLLEAL TVAVVVTFYD 
121:	VYIILQAFIL TTTVFFGLTV YTLQSKKDFS KFGAGLFALL WILCLSGFLK FFFYSEIMEL 
181:	VLAAAGALLF CGFIIYDTHS LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK