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1.B.14.8.3
Vibriobactin receptor, VuiA or VuuA of 687 aas and 1 N-terminal TMS. There is conserved, global coordinate iron regulation in V. cholerae by the Fur transcription factor, responsive to iron (Butterton et al. 1992). V. cholerae synthesizes and uses the catechol siderophore vibriobactin and also uses siderophores secreted by other species, including enterobactin produced by E. coli (Wyckoff et al. 2015).  ViuB, a putative V. cholerae siderophore-interacting protein (SIP), functionally substituted for the E. coli ferric reductase YqjH, which promotes the release of iron from the siderophore in the bacterial cytoplasm. In V. cholerae, ViuB is required for the use of vibriobactin but is not required for the use of MECAM, fluvibactin, ferrichrome, or the linear derivatives of enterobactin, all substrates of ViuA (Wyckoff et al. 2015).

Accession Number:A5F661
Protein Name:Vibriobactin receptor
Length:687
Molecular Weight:76413.00
Species:Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [345073]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate Fe3+-vibriobactin

Cross database links:

Pfam: PF07715   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005506 F:iron ion binding
GO:0004872 F:receptor activity
GO:0015343 F:siderophore transmembrane transporter activity

References (2)

[1] “Cloning, sequencing, and transcriptional regulation of viuA, the gene encoding the ferric vibriobactin receptor of Vibrio cholerae.”  Butterton J.R.et.al.   1317381
[2] “A recalibrated molecular clock and independent origins for the cholera pandemic clones.”  Feng L.et.al.   19115014

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVLCPARVS VAENKKFKLH TLSAMMMGLF TGSFAYAETQ NTSNQEQEMP VLVVIGEKTQ 
61:	RSIYETSASV EVFDQDTIER TPGATEIDDL LQLIPNLVDS GQSNNMPTIR GIDGSGPSVG 
121:	GLASFAGTSP RLNMSIDGRS LTYSEIAFGP RSLWDMQQVE IYLGPQSYIQ GRNTSAGAIV 
181:	MKSNDPTHHF ESAVKAGIGE SDYSQTAGMI SAPIIQDELA FRLSFDQQKR DSFVDLAAFE 
241:	PAGDPKKIEM NSVRGKLLYE PSALDGFKTT LTLSHMDSRG PQTENINVAG NEAFRPVYET 
301:	ASFTTAWDII WHLNDLFTFE NNLVYADFSY DRYTNPNSRG DFNTDGKEFH IEPLLRYIAL 
361:	DGSVNTLIGA RYYQSSQDDM YIDAASAYPM DGRTKAKSVF AEVTYALTPS INVNLAGRFE 
421:	REQVKRNVSH PRYKLDYDET SSVFLPKLDV AYTPVQGQTY GIKAAKGYNA SGAGLAFNSM 
481:	QFTGFRPYEF EQESIWNYEF YTRHRFSHSV EVLTNLFYND FDSMQMTQTT SSGDVFIANL 
541:	DEASTYGAEI GSRWYATSSL ELFANLGLLK TEFKETTGNT KELPRAPKMS ANVGLLYDFG 
601:	QGFEFSSNAA YTGSYFSESG NSEKFAIDSY WVANAQLAYV FEHGRATLYA TNLLDSDKTT 
661:	LYLSTNNTLD QLKQQPRMIG ASVQLNF