1.B.17.3.12
The OMR, SilC, of 490 aas. Francisella tularensis, the causative agent of tularemia, contains three paralogs of OMRs, two, termed as TolC and FtlC, are important for tularemia pathogenesis. The third OM protein SilC, is homologous to the silver cation efflux protein of other bacteria. SilC is encoded in an operon encoding an Emr-type multi-drug efflux pump of F. tularensis. A ΔsilC mutant exhibited increased sensitivity towards antibiotics, oxidants and silver as well as diminished intramacrophage growth and attenuated virulence in mice.
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| Accession Number: | CAJ79125.1 |
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| Protein Name: | CAJ79125.1 outer membrane efflux protein [Francisella tularensis subsp. holarctica LVS] |
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| Length: | 491 |
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| Molecular Weight: | |
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| Species: | Francisella tularensis subsp. holarctica LVS [376619] |
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| Number of TMSs: | 3 |
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| Substrate |
silver(1+), antimicrobial agent, drug, oxidising agent |
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1: MIRNKILPLA LISATLITSS CSFFNPEYER PKIKAPALWN NQDKNIEVTK NWDLTKVAWW
61: REFNDPVLNN LITTALKDNN KLQVSIGNIL QANAEINKAN YGWLPTASVG GGGFVAQAFD
121: VNSNSNIPQL NNIGTQTTAG SLVGIIPSYT INIARQFKLG EISRLSKKMQ TNLKDTTRLS
181: IISQVSAAYF SLITAKEQLK LQTLMVNQLN LMFKYAQNQH KLGATSPMLE EVIRQQLEVQ
241: KGKIAMIKND IVHFQNTLKI LMGRNPGKIV TSRTLNEINA NIKVPINMPS QVLENRPDIG
301: IAEYKLETAN ANIGLARSQF FPSIDLTGTF GNATLALGEL ATMNAWAWAA EAVAAVPVFN
361: LSILADSDKA KAQFYQAYYD YINTLQQAFQ DVDDSLSERA ANAKNLKKQT ISLESTQRQE
421: KIFFKKYSSG AISKAQYTGI TLNVLYQQMQ VNQTKLKSLI SVVNLYQALG SGYNVDNYVD
481: PHYDNPAFDK