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1.B.4 The Brucella-Rhizobium Porin (BRP) Family

The porin proteins in the BRP family are found in the Agrobacterium, Bartonella, Brucella, Mesorhizobium and Rhizobium genuses and are likely to be found in other closely related genera. Brucella species have two homologous outer membrane porins, Omp2a and Omp2b, encoded by two closely linked genes oriented in oppostie directions. Omp2 proteins exist in many size variants due to multiple gene conversions between the two homologous genes that lead to chimeric proteins. These variants show different permeability to sugars as well as different ion conductivities (Paquet et al. 2001Paquet et al. 2001). This family is also called the Omp2 family in SwissProt.

References associated with 1.B.4 family:

Cloeckaert, A., H.S. Debbarh, N. Vizcaino, E. Saman, G. Dubray, and M.S. Zygmunt. (1996). Cloning, nucleotide sequence, and expression of the Brucella melitensis bp26 gene coding for a protein immunogenic in infected sheep. FEMS Microbiol. Lett. 140: 139-144. 8764475
Cloeckaert, A., J.M. Verger, M. Grayon, and N. Vizcaino. (1996). Molecular and immunological characterization of the major outer membrane proteins of Brucella. FEMS Microbiol Lett. 145: 1-8. 8931319
Hohle, T.H., W.L. Franck, G. Stacey, and M.R. O'Brian. (2011). Bacterial outer membrane channel for divalent metal ion acquisition. Proc. Natl. Acad. Sci. USA 108: 15390-15395. 21880957
Jeanteur, D., J.H. Lakey, and F. Pattus. (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760
Jeanteur, D., J.H. Lakey, and F. Pattus. (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall. Edited by Ghuysen, J.M., Hakenbeck, R. Elsevier, Amsterdam, pp. 363-380.
Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213
Paquet, J.Y., M.A. Diaz, S. Genevrois, M. Grayon, J.M. Verger, X. de Bolle, J.H. Lakey, J.J. Letesson, and A. Cloeckaert. (2001). Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp. J. Bacteriol. 183: 4839-4847. 11466287
Paul, S., B.V. Peddayelachagiri, S. Nagaraj, J.J. Kingston, and H.V. Batra. (2018). Recombinant outer membrane protein 25c from Brucella abortus induces Th1 and Th2 mediated protection against Brucella abortus infection in mouse model. Mol Immunol 99: 9-18. 29649688
Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162
Vizcaino, N., A. Cloeckaert, M.S. Zygmunt, and G. Dubray. (1996). Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an immunogenic major outer membrane protein. Infect Immun. 64: 3744-3751. 8751924