TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.C.113.1.1 | The Hly III protein | Bacteria |
Firmicutes | Hly III of Bacillus cereus |
1.C.113.1.2 | Hemolysin III-like protein of 229 aas | Bacteria |
Spirochaetes | Hemolysin III-like protein of Borrelia miyamotoi |
1.C.113.1.3 | Hemolysin D channel protein of the hemolysin III family | Bacteria |
Proteobacteria | Hemolysin D of Pseudomonas stutzeri |
1.C.113.1.4 | Hemolysin III of 205 aas | Bacteria |
Deinococcus-Thermus | Hemolysin of Thermus thermophilus |
1.C.113.1.5 | Hemolysin III-like protein of 407 aas | Eukaryota |
Bangiophyceae | Hemolysin of Galdieria sulphuraria (Red alga) |
1.C.113.1.6 | Putative hemolysin III of 262 aas | Bacteria |
Actinobacteria | Hemolysin of Corynebacterium diphtheriae |
1.C.113.1.7 | Hemolysin of 282 aas, HlyIII; forms pores of ~3.2 nm for solutes and ions (Wunderlich 2022). | Eukaryota |
Apicomplexa | Hemolysin of Plasmodium falciparum |
1.C.113.1.8 | Adiponectin receptor protein of 340 aas | Eukaryota |
Kinetoplastida | Adiponectin receptor of Trypanosoma cruzi |
1.C.113.1.9 | The adiponectin receptor 1 or ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017). It may function with adiponectin to stimulate cholesterol efflux via ABCA1 (Hafiane et al. 2019). The Tyr-Pro dipeptide may function as an AdipoR1 agonist (Lee et al. 2021).
| Eukaryota |
Metazoa | ADIPOR1 of Homo sapiens |
1.C.113.1.10 | YqfA protein of unknown function. It may play a role in furfural resistance (Miller et al. 2009). | Bacteria |
Proteobacteria | YqfA of E. coli |
1.C.113.1.11 | ADIPOR2 of 387 aas and 7 TMSs. It may funtion in promoting cholesterol efflux together with ADIPOR1 and adiponectin (Hafiane et al. 2019). | Eukaryota |
Metazoa | Adiponectin receptor 2, ADIPOR2, of Homo sapiens |
1.C.113.1.12 | Progestin (P4) receptor beta of 354 aas and 8 TMSs. It couples to G proteins (Petersen et al. 2013). It seems to act through a Gi mediated pathway and may be involved in oocyte maturation (Petersen et al. 2013). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (Pang et al. 2013). | Eukaryota |
Metazoa | Progesterone receptor of Homo sapiens |
1.C.113.2.1 | The monocyte to macrophage differentiation protein (MMDP) | Eukaryota |
Metazoa | MMDP of Homo sapiens |
1.C.113.2.2 | Monocyte to macrophage differentiation factor 2 of 363 aas and 7 TMSs | Eukaryota |
Metazoa | Hemolysin homologue of Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
1.C.113.2.3 | Progestin and adipoQ receptor family member 10, PAQR10, of 270 aas and 7 TMSs. Also called Monocyte to macrophage differentiation factor 2, MMD2. PAQR10 is structurally related to some bacterial hemolysins, pore-forming virulence factors that target mitochondria and regulate apoptosis (Góñez et al. 2008). | Eukaryota |
Metazoa | PAQR10 of Homo sapiens |