TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.75.1.1









The Serratia pore-forming hemolysin/toxin of 1608 aas, ShlA. ShlA expression allows Serratia to trigger a Ca2+ signal that reshapes cytoskeleton dynamics and ends up pushing the Serratia-containing vacuoles out of the cell in an exocytic-like process (Di Venanzio et al. 2016). Thus, pore-forming toxins can allow bacteria to exit without compromising host cell integrity. ShlA triggers cadherin cleavage by promoting calcium influx which activates ADAM10 for proteolysis (Reboud et al. 2017).

Bacteria
Proteobacteria
ShlA of Serratia marcescens (P15320)
1.C.75.1.2









Haemolysin of 3456 aas. Hemagglutinin repeat-containing protein.

Bacteria
Proteobacteria
Haemolysin of Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
1.C.75.1.3









Two-partner secretion system hemagglutinin TpsA2 of 2521 aas

Bacteria
Proteobacteria
Haemagglutinin of Pseudomonas aeruginosa
1.C.75.1.4









Filamentous hemagglutinin protein of 1599 aas.  It is a two-partner secretion exoprotein, HrpA.

Bacteria
Proteobacteria
Filamentous hemagglutinin of Neisseria meningitidis
1.C.75.1.5









Haemolysin XhlA of 1470 aas with 1 N-terminal TMS (Cowles and Goodrich-Blair 2005).

Bacteria
Proteobacteria
XhlA of Xenorhabdus nematophila (Achromobacter nematophilus)
1.C.75.1.6









Exotoxin, ChlA of 1628 aas (Brumbach et al. 2007).

Bacteria
Proteobacteria
1.C.75.1.7









Filamentous haemagglutinin family outer membrane protein of 2818 aas.

Bacteria
Proteobacteria
Haemagglutinin of Burkholderia ambifaria
1.C.75.1.8









Cytopathogenic toxin, CptA, of 1991 aas and an N-terminal signal TMS. Sneathia amnii is a poorly characterized emerging pathogen that has been implicated in amnionitis and urethritis. Gentile et al. 2020 found that S. amnii damages fetal membranes, and they identified and purified the cytotoxic exotoxin, CptA, that lyses human red blood cells and damages cells from fetal membranes. It binds to red blood cell membranes and forms pores with a diameter of 2.0-3.0 nanometers, resulting in osmolysis.

Bacteria
Fusobacteria
CptA of Sneathia amnii