| |
|---|---|
| Accession Number: | P18581 |
| Protein Name: | CTR2 aka CAT2 aka TEA aka SLC7A2 aka ATRC2 |
| Length: | 657 |
| Molecular Weight: | 71866.00 |
| Species: | Mus musculus (Mouse) [10090] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | lysine, ornithine, arginine |
Cross database links:
| RefSeq: | NP_031540.2 |
|---|---|
| Entrez Gene ID: | 11988 |
| Pfam: | PF00324 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005289
F:high affinity arginine transmembrane transp...
GO:0015189
F:L-lysine transmembrane transporter activity
GO:0000064
F:L-ornithine transmembrane transporter activity
GO:0015809
P:arginine transport
GO:0015807
P:L-amino acid transport
GO:0015819
P:lysine transport
GO:0042116
P:macrophage activation
GO:0006809
P:nitric oxide biosynthetic process
GO:0015822
P:ornithine transport
GO:0002537
P:production of nitric oxide involved in infl...
GO:0050727
P:regulation of inflammatory response
GO:0043030
P:regulation of macrophage activation
GO:0055085
P:transmembrane transport
| |
References (9)[1] “Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor.” Macleod C.L.et.al. 1694015 [2] “Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.” Closs E.I.et.al. 8385111 [3] “Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family.” Kavanaugh M.P.et.al. 8195186 [4] “Regulating gene expression through RNA nuclear retention.” Prasanth K.V.et.al. 16239143 [5] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages.” Yeramian A.et.al. 16670299 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTVDLI ALGVGSTLGA GVYVLAGEVA 61: KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI 121: LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL 181: SFGVKESAWV NKFFTAINIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG 241: TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 301: MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVRWGPAKYV VAAGSLCALS TSLLGSMFPL 361: PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM AFLFDLKALV DMMSIGTLMA 421: YSLVAACVLI LRYQPGLCYE QPKYTPEKET LESCTNATLK SESQVTMLQG QGFSLRTLFS 481: PSALPTRQSA SLVSFLVGFL AFLILGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI 541: LTIWRQPQNQ QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWIRFSIWM ALGFLIYFAY 601: GIRHSLEGNP RDEEDDEDAF SENINVATEE KSVMQANDHH QRNLSLPFIL HEKTSEC