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2.A.3.8.2 L-type neutral amino acid transporter, ASUR4 (Na⁺-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters (Su et al. 2005).
Accession Number:	O13020
Protein Name:	ASUR4
Length:	507
Molecular Weight:	55530.00
Species:	Xenopus laevis (African clawed frog) [8355]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cytoplasm¹ / Multi-pass membrane protein²
Substrate	alpha-amino acid

Pfam:	PF00324
Gene Ontology GO:0016021 C:integral to membrane GO:0015171 F:amino acid transmembrane transporter activity GO:0006865 P:amino acid transport GO:0055085 P:transmembrane transport
References (2) [1] “Characterization of early aldosterone-induced RNAs in A6 kidney epithelia.” Spindler B.et.al. 9178633 [2] “Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.” Mastroberardino L.et.al. 9751058

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAADSVKRRQ SGASKTEEED RQAAEKMLHQ NGNAEPKSGD GGAVELQRTI TLVNGVAIIV 
61:	GTIIGSGIFV TPTGVLREAG SPGLSLLVWA VCGLFSIVGA LCYAELGTTI SKSGGDYAYV 
121:	LEVYGALPAF LKLWVELLII RPSSQYIVAL VFATYLLKPV FPTCPVPDDA AKIVACLCIL 
181:	LLTAINCYSV KAATRVQDAF AAAKLLALFL IIILGFVQLG KGGVEDLKPE RSFEGTSTNV 
241:	GQWVLALYSG LFAYGGWNYL NFVVEEMIEP YKNLPRAIII SMPIVTLVYV LTNLAYFTTL 
301:	TPEQMLNSEA VAVDFGNYHL GVMAWIIPVF VGLSCFGSVN GSLFTSSRLF FVGAREGHLP 
361:	SLLAMIHPRL LTPMPSLIFT CAMTLLYAFS NDIFSVINFF SFFNWLCVAL AIIGMMWLRY 
421:	KKPELERPIK VNILLPIFFI LACIFLIVVS FYMTPVECGI GFIIILTGVP VYFFGVWWQN 
481:	KPDWILHGIH SSTALLQKVM EAVPQES

2.A.3.8.2
L-type neutral amino acid transporter, ASUR4 (Na⁺-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters (Su et al. 2005).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.3.8.2L-type neutral amino acid transporter, ASUR4 (Na+-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters (Su et al. 2005).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.3.8.2
L-type neutral amino acid transporter, ASUR4 (Na⁺-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters (Su et al. 2005).