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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
2.A.37.1.1	Glutathione-regulated K⁺ efflux protein C, KefC; regulated by ancillary protein KefF (YabF)	Bacteria	Pseudomonadota	KefCF of E. coli KefC (P03819) KefF (P0A754)
2.A.37.1.2	Glutathione-regulated K⁺ efflux protein B, KefB; regulated by ancillary protein KefG (YheR)	Bacteria	Pseudomonadota	KefBG of E. coli KefB (P45522) KefG (P0A756)
2.A.37.1.3	The K ⁺ efflux pump, KefB (Wei et al., 2007)	Bacteria	Pseudomonadota	KefB of Alkalimonas amylolytica (Q0ZAH7)
2.A.37.1.4	K⁺ efflux antiporter 1, chloroplastic (AtKEA1). It localizes to the chloroplast inner envelope membrane and is essential for normal osmoregulation (Kunz et al. 2014). It has an even number of TMSs, probably 14, with N- and C-terminal hydrophilic regulatory domains (Bölter et al. 2019).	Eukaryota	Viridiplantae, Streptophyta	KEA1 of Arabidopsis thaliana
2.A.37.1.5	Inner membrane protein, YbaL or KefB: glutathione-regulated potassium-efflux system protein.	Bacteria	Pseudomonadota	YbaL of Escherichia coli
2.A.37.1.6	K⁺ efflux - K⁺:H⁺ antiporter 3 (AtKEA3) of 776 aas and 13 TMSs. Localizes to the thylakoid membrane of the chloroplast. It modulates pmf partitioning through H⁺ efflux from the lumen, which is critical for photosynthetic acclimation after transitions from high to low light intensity (Armbruster et al. 2014; Kunz et al. 2014). It has an even number of TMSs, probably 14 (Bölter et al. 2019), with hydrophilic N- and C-terminal regulatory domains.	Eukaryota	Viridiplantae, Streptophyta	KEA3 of Arabidopsis thaliana
2.A.37.1.7	Chloroplastic K⁺ efflux antiporter 2, AtKEA2. Cation preference: K⁺ > Cs⁺ > Li⁺ > Na⁺(Aranda-Sicilia et al. 2012). The N-terminal hydrophilic domain show sequence similarity to members of the MPA1-C family (8.A.3.1.2). Localizes to the chloroplast inner envelope membrane and plays a role in chloroplast integrity (Kunz et al. 2014). It is up-regulated under salt stress conditions (Yang et al. 2018 Yang et al. 2018).	Eukaryota	Viridiplantae, Streptophyta	KEA2 of Arabidopsis thaliana
2.A.37.1.8	K⁺ efflux antiporter 5 (AtKEA5)	Eukaryota	Viridiplantae, Streptophyta	KEA5 of Arabidopsis thaliana
2.A.37.1.9	Glutathione-regulated potassium-efflux system, KefB of 416 aas and 13 TMSs.	Bacteria	Campylobacterota	KefB of Helicobacter pylori
2.A.37.1.10	CPA2 family member of 627 aas and 12 TMSs	Bacteria	Pseudomonadota	CPA2 member of Simonsiella muelleri
2.A.37.1.11	Transmembrane and coiled-coil domain 3, TMCO3, of 677 aas and 13 TMSs in a 1 (N-terminus) + 4 + 2 + 2 + 4 TMS (residues 255 - 670) arrangement. When mutated, it causes cornea guttata and anterior polar cataracts (Chen et al. 2016). The encoding gene is expressed in the human cornea, lens capsule, and choroid-retinal pigment epithelium (Chen et al. 2016). It is a prognostic biomarker that correlates with immune infiltration in hepatocellular carcinoma (Deng et al. 2021). TMCO3 may be a biomarker for liver hepatocellular carcinoma (LIHC) prognosis and immunotherapy (Hu et al. 2022).	Eukaryota	Metazoa, Chordata	TMCO3 of Homo sapiens
2.A.37.1.12	Iron-regulated MagA protein. Deletion mutants of magA show apparently normal magnetosomes and growth in spite of an early report to the contrary (Uebe et al. 2012).	Bacteria	Pseudomonadota	MagA of Magnetospirillum sp. strain AMB-1
2.A.37.1.13	K⁺ efflux antiporter 4, Kea4, of 592 aas and 14 TMSs in a 1 + 13 TMS arrangement.	Eukaryota	Viridiplantae, Streptophyta	Kea4 of Arabidopsis thaliana
2.A.37.2.1	Na⁺:H⁺ antiporter, NapA	Bacteria	Bacillota	NapA of Enterococcus hirae
2.A.37.2.2	The Na⁺/H⁺-K⁺ antiporter, GerN (spore germination protein-N) (Southworth et al., 2001).	Bacteria	Bacillota	GerN of Bacillus cereus
2.A.37.2.3	Spore germination protein, GrmA. PTS IIA-like nitrogen-regulatory protein modulated sodium/hydrogen exchanger.	Bacteria	Bacillota	GrmA of Bacillus megaterium
2.A.37.2.4	The high-affinity (Km(Na⁺)=0.7 mM) Na⁺(Li⁺):H⁺ thylakoid membrane antiporter, NhaS3 (essential for growth; promotes Na⁺ resistance; expressed in the presence of high CO₂concentrations; under circadian control (Tsunekawa et al. 2009).	Bacteria	Cyanobacteriota	NhaS3 of Synechocystis sp. PCC6803
2.A.37.2.5	Na⁺/H⁺ exchanger of 732 aas. The exchanger is the N-terminal domain, and the C-terminal domain is in the cl00292 superfamily of adenine nucleotide alpha hydrolases. This superfamily includes N-type ATP PPases, ATP sulphurylases, Universal Stress Response proteins and electron transfer flavoproteins (ETF). The domain forms a apha/beta/apha fold which binds to adenosine nucleotides.	Bacteria	Chlorobiota	NHA homologue of Chlorobium limicola
2.A.37.2.6	Putative Na⁺:H⁺ antiporter of 388 aas and 10 TMSs, Nha.	Bacteria	Bdellovibrionota	Nha of Bdellovibrio bacteriovorus
2.A.37.2.7	Na⁺/H⁺ antiporter of 386 aas and 13 predicted TMSs, NapA. The 3-d structure is known (PDB# 4BWZ; 4BZ2; 4BZ3). In the NapA structure, the core and dimerization domains are in different positions to those seen in the E. coli NhaA, and a negatively charged cavity is open to the outside. The extracellular cavity allows access to a strictly conserved aspartate residue thought to coordinate ion binding directly. To alternate access to this ion-binding site, however, requires a surprisingly large rotation of the core domain, some 20° against the dimerization interface (Lee et al. 2013). A transmembrane lysine residue is essential for electrogenic transport in this and related Na+/H+ antiporters(Uzdavinys et al. 2017).	Bacteria	Deinococcota	NapA of Thermus thermophilus
2.A.37.3.1	Bacterial CPA2 homologue, KefC, a predicted glutathione-regulated potassium-efflux system.	Bacteria	Myxococcota	CPA2 homologue of Myxococcus xanthus
2.A.37.3.2	Monovalent cation antiporter with CBS domain pair of 577 aas.	Bacteria	Thermodesulfobacteriota	CPA protein of Pelobacter carbinolicus
2.A.37.3.3	Putative Na⁺:H⁺ antiporter of 438 aas and 13 TMSs.	Bacteria	Spirochaetota	NHA protein of Salinispira pacifica
2.A.37.4.1	K⁺:H⁺ antiporter, Kha1 (YJL094c)	Eukaryota	Fungi, Ascomycota	Kha1 of Saccharomyces cerevisiae
2.A.37.4.2	Endosome and prevacuole K⁺:H⁺ antiporter, CHX17 of 820 aas and 13 putative TMSs. Mediates potassium ion and pH homeomeostasis, thereby influencing membrane trafficking (Chanroj et al. 2011). May also catalyze Na⁺/H⁺ antiport (Sze and Chanroj 2018). CHX can promote the uptake of K⁺, increase the ratio of K⁺/Na⁺, and promote the growth of plants under K⁺ deficiency and treatment with NaCl solution (Guo et al. 2023). acquisition and homeostasis.	Eukaryota	Viridiplantae, Streptophyta	CHX17 of Arabidopsis thaliana (AAX49545)
2.A.37.4.3	Plasma membrane K⁺ uptake transporter, CHX13 (K_m ≈ 150μM; expressed in roots) (Zhao et al., 2008)	Eukaryota	Viridiplantae, Streptophyta	CHX13 of Arabidopsis thaliana (O22920)
2.A.37.4.4	CHX08 cation:H⁺ antiporter (expressed in pollen; Bock et al., 2006) (most like 2.A.37.4.3; 29% identity)	Eukaryota	Viridiplantae, Streptophyta	CHX08 of Arabidopsis thaliana (Q58P71)
2.A.37.4.5	Cation/H(+) antiporter 23, chloroplastic (Protein CATION/H+ EXCHANGER 23) (AtCHX23)	Eukaryota	Viridiplantae, Streptophyta	CHX23 of Arabidopsis thaliana
2.A.37.4.6	Cation/H(+) antiporter 26 (Protein CATION/H+ EXCHANGER 26) (AtCHX26)	Eukaryota	Viridiplantae, Streptophyta	CHX26 of Arabidopsis thaliana
2.A.37.4.7	Cation C⁺/H⁺ antiporter 1 (Protein CATION/H⁺ EXCHANGER 1) (AtCHX1). CHX transporters play roles in salt tolerance in A thaliana seedlings (Guo et al. 2023). They promote the uptake of K⁺, increase the ratio of K⁺/Na⁺, and promote the growth of plants under K⁺ deficiency and treatment with NaCl solutions. Thus, CHXs are involved in K⁺ transport and improve plant salt tolerance by coordinating K⁺acquisition and homeostasis. (Guo et al. 2023).	Eukaryota	Viridiplantae, Streptophyta	CHX1 of Arabidopsis thaliana
2.A.37.4.8	Endoplasmic reticular K⁺/H⁺ antiporter, CHX20. Maintains pH and K⁺ homeostasis in guard cells. Plays a critical role in osmoregulation through the control of stomates opening. Regulates alkaline pH-sensitive growth and influences membrane trafficking (Chanroj et al. 2011).	Eukaryota	Viridiplantae, Streptophyta	CHX20 of Arabidopsis thaliana
2.A.37.5.1	The bidirectional K⁺/NH₄⁺ transporter, AmhT (ammonium homeostasis transporter) (Fujisawa et al., 2007)	Bacteria	Bacillota	AmhTM of Bacillus pseudoforinus AmhT (390 aas) (O50576) AmhM (167 aas) (O50575)
2.A.37.5.2	The K ⁺/H⁺ antiporter, YhaTU (Fujisawa et al., 2007)	Bacteria	Bacillota	YhaTU of Bacillus subtilis YhaT (165 aas) (O07535) YhaU (408 aas) (O07536)