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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
2.A.52.1.1	High affinity Ni²⁺-specific transporter, HoxN (Hebbeln and Eitinger 2004).	Bacteria	Pseudomonadota	HoxN of Ralstonia eutropha
2.A.52.1.2	Co²⁺ transporter, NhlF (also transports Ni²⁺ with low affinity) (Hebbeln and Eitinger 2004).	Bacteria	Actinomycetota	NhlF of Rhodococcus rhodochrous
2.A.52.1.3	Ni²⁺ -specific transporter, Nic1p (Eitinger et al. 2000).	Eukaryota	Fungi, Ascomycota	Nic1p of Schizosaccharomyces pombe
2.A.52.1.4	High affinity Ni²⁺ uptake porter, NixA. Transcription is regulated by NixR (Wolfram et al. 2006). The metal selectivity and translocation mechanism in proteoliposomes of the transmembrane NiCoT transporter NixA from Helicobacter pylori have been reported (Hernandez et al. 2024).	Bacteria	Campylobacterota	NixA of Helicobacter pylori
2.A.52.1.5	NisA of 350 aas and 8 TMSs (Hebbeln and Eitinger 2004; Deng et al. 2013).	Bacteria	Bacillota	NisA of Staphylococcus aureus
2.A.52.1.6	HupN of 381 aas and 8 TMSs (Hebbeln and Eitinger 2004 Hebbeln and Eitinger 2004; Deng et al. 2013).	Bacteria	Pseudomonadota	HupN of Brandyrhizobium japonicum
2.A.52.1.7	NicT is a heavy metal transporter of 372 aas with 8 TMSs in a 4 + 4 TMS arrangement suggesting of a 4 TMS repeat unit. Actually it looks like a 2 + 2 + 2 + 2 arrangement. It is a NiCoT family transporter of Mycobacterium tuberculosis (Rv2856/NicT). It also behaves as a drug efflux pump that facilitates cross-resistance to antibiotics (Adhikary et al. 2022).	Bacteria	Actinomycetota	NicT of Mycobacterium tuberculosis
2.A.52.1.8	Putative high affinity nickel ion uptake transporter of 413 aas and 8 TMSs	Eukaryota	Fungi, Ascomycota	Nickel transporter of Neurospora crassa
2.A.52.1.9	NicO homologue of 363 aas and 6 TMSs	Eukaryota	Haptophyta	NicO of Emailiania huxleyi
2.A.52.2.1	Putative Ni²⁺/Co²⁺ uptake transporter of 277 aas and 7 TMSs.	Bacteria	Nitrospirota	Nickel/cobalt transporter of Leptospirillum ferroxidans
2.A.52.2.2	Putative Ni²⁺/Co²⁺ transporter of 269 aas and 7 TMSs.	Bacteria	Pseudomonadota	Nickel/cobalt transporter of Dechloromonas aromatica
2.A.52.2.3	Putative Ni²⁺/Co²⁺ uptake porter of 220 aas and 6 TMSs.	Bacteria	Deinococcota	Nickel/cobalt porter of Thermus thermophilus
2.A.52.2.4	Putative nickel/cobalt porter of 227 aas and 6 TMSs	Bacteria	Deinococcota	Ni²⁺ porter of Deinococcus deserti
2.A.52.2.5	Putative transporter of 274 aas and 6 TMSs.	Bacteria	Bacteroidota	Transporter of Chitinophaga pinensis
2.A.52.2.6	NiCoT homologue of 224 aas and 6 TMSs.	Bacteria	Cyanobacteriota	NiCoT family member of Gloeobacter violaceus