| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
2.A.71.1.1 | BT1 biopterin/folate (not methotrexate) transporter | Eukaryota |
Euglenozoa | BT1 (OrfG) of Leishmania donovani |
|
2.A.71.1.2 | Biopterin transporter | Eukaryota |
Euglenozoa | BT1 of Leishmania mexicana |
|
2.A.71.1.3 | FT1 folate/biopterin transporter. This protein is nearly identical to the functionally characterized protein from L. infantum (2.A.71.1.5) which is a high affinity S-adenosyl methione uptake porter. Therefore the annotation shown above may be incorrect and this protein may also be an S-adenosyl methionine uptake porter (Dridi et al. 2010). | Eukaryota |
Euglenozoa | FT1 of Leishmania donovani |
|
2.A.71.1.4 | FT1 (ESAG10) folate/biopterin transporter | Eukaryota |
Euglenozoa | ESAG10 of Trypanosoma brucei |
|
2.A.71.1.5 | High affinity plasma membrane constitutively synthesized S-Adenosylmethionine (AdoMet) uptake transporter, AdoMetT1 of 706 aas. It also takes up the AdoMet analogue, Sinefungin (Dridi et al. 2010). This protein is nearly identical to 2.A.71.1.3 which may also be an AdoMet uptake transporter (by sequence similarity). | Eukaryota |
Euglenozoa | AdoMetT1 of Leishmania infantum |
|
2.A.71.1.6 | Folate/biopterin/methotrexate transporter, BT1, of 1057 aas and 14 TMSs in the N-terminal half of the protein (residues 1 - 500) with an equally long C-terminal hydrophilic domain. Uptake of folate across the parasite plasma membrane is rapid, biphasic, temperature dependent, bi-directional, concentration dependent and specific (Massimine et al. 2005).
| Eukaryota |
Apicomplexa | BT1 of Toxoplasma gondii |
|
2.A.71.2.1 | Functionally uncharacterized Orf | Bacteria |
Cyanobacteriota | Orf of Synechococcus (PCC7942) |
|
2.A.71.2.2 | Folate/biopterin uptake carrier, Fbp. Transports 5-formyl tetrahydrofolate monoglutamate but not 5-formyltetrahydrofolate triglutamate. (Also transports methotrexate and aminopterin) (Klaus et al., 2005) (Nine homologues are present in Arabidopsis thaliana.) (Klaus et al., 2005). Mutational analyses suggest that the folate binding site involves the core helices 1, 4, 7 and 10 and is in the center of the membrane (Eudes et al., 2010). | Eukaryota |
Viridiplantae, Streptophyta | Fbp of Arabidopsis thaliana (Q9SKZ5) |
|
2.A.71.2.3 | Folate/biopterin uptake carrier of 494 aas, Fbp (also transports methotrexate and aminopterin) (Klaus et al., 2005). Essential residues line the central cavity (based on the LacY structure) in TMSs 1, 4, 7 and 10 (Eudes et al. 2010). | Bacteria |
Cyanobacteriota | Fbp (Srl0642) of Synechocystic sp. PCC6803 (BAA10362) |
|
2.A.71.2.4 | Folate transporter 3, FT3 of 537 aas and 14 putative TMSs. | Bacteria |
Pseudomonadota | FT3 of Nitrosospira lacus |
|
2.A.71.2.5 | Uncharacterized protein of 551 aas and 13 - 14 TMSs. | Eukaryota |
Oomycota | UP of Phytophthora parasitica |
|
2.A.71.2.6 | Folate transporter, BP1, of 442 aas and 12 TMSs. | Eukaryota |
Viridiplantae, Streptophyta | BP1 of Arabidopsis thaliana |
|
2.A.71.2.7 | Folate/pABA/5-methyltetrahydrofolate transporter, putative, of 505 aas with 12 TMSs in a 6 + 6 TMS arrangement. | Eukaryota |
Apicomplexa | Folate transporter of Plasmodium falciparum |