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8.A.111.  The Store-operated Ca2+ Entry-associated Regulatory Factor (SARAF) Family. 

Members of this family can be found in animals and many other eukaryotes of many types, but not in prokaryotes. SARAF is a negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. In response to cytosolic Ca2+ elevation after endoplasmic reticulum Ca2+ refilling, a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity occurs. This mechanisms possibly acts by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca2+ levels. It would thus prevent the overload of the cell with excessive Ca2+ ions (Dai et al. 2018). Overexpressing SARAF ameliorates pressure overload-induced cardiac hypertrophy through supprssing STIM1-Orai in mice. Thus, overexpression of SARAF in the heart prevents cardiac hypertrophy, probably by suppressing the upregulation of STIM1/Orai1 (Dai et al. 2018).


References associated with 8.A.111 family:

Dai, F., Y. Zhang, Q. Wang, Li, Y. Yang, S. Ma, and D. Yang. (2018). Overexpression of SARAF Ameliorates Pressure Overload-Induced Cardiac Hypertrophy Through Suppressing STIM1-Orai1 in Mice. Cell Physiol Biochem 47: 817-826. 29807359
Saldías, M.P., P. Cruz, I. Silva, O. Orellana-Serradell, B. Lavanderos, D. Maureira, R. Pinto, and O. Cerda. (2023). The Cytoplasmic Region of SARAF Reduces Triple-Negative Breast Cancer Metastasis through the Regulation of Store-Operated Calcium Entry. Int J Mol Sci 24:. 36982380
Yang, J., S. Li, Q. Wang, and D. Yang. (2019). Transmembrane protein 66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation. Mol Med Rep 20: 1436-1442. 31173198