| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.111.1.1 | Store operated calcium entry (SOCE)-associated regulatory factor, SARAF, ia of 339 aas with 2 or 3 TMSs. Overexpression of SARAF in the heart prevents cardiac hypertrophy, probably through suppressing the upregulation of STIM1/Orai1 (Dai et al. 2018). TMEM66 attenuates neointimal hyperplasia after carotid artery injury by store operated calcium entry (SOCE) inactivation. It confers vascular protection against balloon injury (Yang et al. 2019). Regulating the activity of the SOCE response via SARAF activity may allow therapeutic strategies for triple-negative breast cancer (Saldías et al. 2023). | Eukaryota |
Metazoa, Chordata | SARAF of Homo sapiens |
|
8.A.111.1.2 | SARAF of 316 aas and 2 or 3 TMSs. | Eukaryota |
Metazoa, Nematoda | SARAF of Caenorhabditis elegans |
|
8.A.111.1.3 | DUF1183 domain-containing protein of 357 aas and 2 TMSs. | Eukaryota |
Fungi, Ascomycota | SARAF homologue of Neurospora crassa |
|
8.A.111.1.4 | Uncharacterized protein of 299 aas and 3 TMSs. | Eukaryota |
Rhodophyta | UP of Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa) |
|
8.A.111.1.5 | Uncharacterized protein of 253 aas and 2 or 3 TMSs. | Eukaryota |
Fungi, Mucoromycota | UP of Bifiguratus adelaidae |
|
8.A.111.1.6 | Uncharacterized protein of 765 aas and 2 or 3 TMSs | Eukaryota |
Metazoa, Arthropoda | UP of Tropilaelaps mercedesae |
|
8.A.111.1.7 | Uncharacterized protein of 310 aas and 3 TMSs | Eukaryota |
Viridiplantae, Streptophyta | UP of Chara braunii |
|
8.A.111.1.8 | Uncharacterized protein of 351 aas and 2 TMSs | Eukaryota |
UP of Ectocarpus siliculosus | |
|
8.A.111.1.9 | Uncharacterized protein of 802 aas and 2 TMSs. | Eukaryota |
Metazoa, Mollusca | UP of Crassostrea virginica |