TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.120.1.1









StarD7 of 370 aas and 2 TMSs.  See family description and (Horibata et al. 2017) for a functional description.

Eukaryota
Metazoa, Chordata
StarD7 of Homo sapiens
8.A.120.1.2









Uncharacterized StarD7-like phosphatidyl choline transfer protein, PCTP-like protein, of 267 aas and 0 TMSs, containing a START domain. 

Eukaryota
Metazoa, Chordata
UP of Neolamprologus brichardi
8.A.120.1.3









Uncharacterized protein of 311 aas and 0 TMSs.

Eukaryota
Euglenozoa
UP of Trypanosoma theileri
8.A.120.1.4









Uncharacterized protein of 217 aas

Bacteria
Pseudomonadota
UP of Acinetobacter baumannii
8.A.120.1.5









Uncharacterized protein of 244 aas

Bacteria
Spirochaetota
UP of Turneriella parva
8.A.120.1.6









Uncharacterized polyketide cyclase/dehydrase and lipid transport superfamily protein of 294 aas and 2 N-terminal TMSs. 

Eukaryota
Viridiplantae, Streptophyta
UP of Arabidopsis thaliana
8.A.120.2.1









The metastatic lymph node-64 (MLN-64; MLN64; STARD3; CAB1) protein mediates endosomal cholesterol transport to mitochondria and the plasma membrane (Kennedy et al. 2014). It has been implicated in toxin-induced resistance. Down-regulation of MLN64 in Niemann-Pick C1 deficient cells decreased mitochondrial cholesterol content, suggesting that MLN64 functions independently of NPC1 (Balboa et al. 2017), and overexpression increases the mitochondrial cholesterol content and decreases the mitochondrial glutathione content, leading to mitochondrial dysfunction (Balboa et al. 2017). STARD3 is a key protein in the cholesterol movement in cancer cells (Asif et al. 2021). STARD3 is also a lutein- and zeaxanthin (carotenoid)-binding protein (Arunkumar et al. 2020).

Eukaryota
Metazoa, Chordata
MLN-64 of Homo sapiens (Q14849)
8.A.120.2.2









The Start1 protein (putative cholesterol transporter)
Eukaryota
Metazoa, Arthropoda
Start1 protein of Drosophila melanogaster (AAR19767)
8.A.120.2.3









STARD3 N-terminal-like protein, STARD3NL (MENTHO) of 234 aas and 3 TMSs.  MLN64 (metastatic lymph node 64) and MENTHO (MLN64 N-terminal homologue) are two late-endosomal proteins that share a conserved region of four transmembrane helices with three short intervening loops called the MENTAL domain (MLN64 N-terminal domain) (Alpy and Tomasetto 2006). This domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol in vivo. In addition to the MENTAL domain, MLN64 contains a cholesterol-specific START domain [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain]. The START domain is a protein module of approx. 210 residues that binds lipids, including sterols, and is present in 15 distinct proteins in mammals. Thus MLN64 and MENTHO define discrete cholesterol-containing subdomains within the membrane of late endosomes where they may function in cholesterol transport. The MENTAL domain might serve to maintain cholesterol at the membrane of late endosomes prior to its shuttle to cytoplasmic acceptor(s) through the START domain (Alpy and Tomasetto 2006).

Eukaryota
Metazoa, Chordata
STARD3NL of Homo sapiens
8.A.120.3.1









STAR-related lipid transfer protein, STARD4, of 205 aas and 0 TMSs.  It is involved in the intracellular transport of cholesterol; it binds cholesterol or other sterols (Rodriguez-Agudo et al. 2008).

Eukaryota
Metazoa, Chordata
STARD4 of Homo sapiens