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8.A.129.  The Blood Vessel Epicardial Substance (BVES) Family 

BVES os a cell adhesion molecule involved in the establishment and/or maintenance of cell integrity, and the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (Osler et al. 2005). It also plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. It induces primordial adhesive contact and aggregation of epithelial cells in a Ca2+-independent manner and is involved in striated muscle regeneration and repair, and in the regulation of cell spreading. It plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 while enhancing current density (Schindler et al. 2016).

References associated with 8.A.129 family:

Osler, M.E., M.S. Chang, and D.M. Bader. (2005). Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci 118: 4667-4678. 16188940
Schindler, R.F., C. Scotton, J. Zhang, C. Passarelli, B. Ortiz-Bonnin, S. Simrick, T. Schwerte, K.L. Poon, M. Fang, S. Rinné, A. Froese, V.O. Nikolaev, C. Grunert, T. Müller, G. Tasca, P. Sarathchandra, F. Drago, B. Dallapiccola, C. Rapezzi, E. Arbustini, F.R. Di Raimo, M. Neri, R. Selvatici, F. Gualandi, F. Fattori, A. Pietrangelo, W. Li, H. Jiang, X. Xu, E. Bertini, N. Decher, J. Wang, T. Brand, and A. Ferlini. (2016). POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking. J Clin Invest 126: 239-253. 26642364
Yau, K.W. (1994). Cyclic nucleotide-gated channels: an expanding new family of ion channels. Proc. Natl. Acad. Sci. USA 91: 3481-3483. 7513422