8.A.132.2.1
Tissue factor F3 of 295 aas and 2 TMSs, N- and C-terminal. It initiates blood coagulation by forming a complex
with circulating factor VII or VIIa. The [TF:VIIa] complex activates
factors IX or X by specific limited proteolysis. TF plays a role in
normal hemostasis by initiating the cell-surface assembly and
propagation of the coagulation protease cascade (Bogdanov et al. 2003).
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| Accession Number: | P13726 |
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| Protein Name: | Tissue factor |
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| Length: | 295 |
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| Molecular Weight: | 33068.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK
61: PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS
121: AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG
181: KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE
241: CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS