TCDB is operated by the Saier Lab Bioinformatics Group

8.A.132. The Interferon/Interleukin Receptor (IIR) Family 

Interferon and interleukin receptors are thought to have evolved from a common ancestor in the early jawed vertebrates (Secombes and Zou 2017). The Supressor of Lurcher 1, SOL1 (TC# 8.A.132.1.1), of 557 aas and 2 TMSs, one N-terminal and one C-terminal, is a homolog of these receptors. SOL1 proteins regulate ionotropic glutamate receptor desensitization (Walker et al. 2006). SOL1 is an accessory protein requlred for glutamate-gated currents by Glr-1 (Zheng et al. 2004). This protein has an internal duplication and belongs to the FN3 superfamily.

References associated with 8.A.132 family:

Bogdanov, V.Y., V. Balasubramanian, J. Hathcock, O. Vele, M. Lieb, and Y. Nemerson. (2003). Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat. Med. 9: 458-462. 12652293
Secombes, C.J. and J. Zou. (2017). Evolution of Interferons and Interferon Receptors. Front Immunol 8: 209. 28303139
Walker, C.S., M.M. Francis, P.J. Brockie, D.M. Madsen, Y. Zheng, and A.V. Maricq. (2006). Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Proc. Natl. Acad. Sci. USA 103: 10787-10792. 16818875
Zheng, Y., J.E. Mellem, P.J. Brockie, D.M. Madsen, and A.V. Maricq. (2004). SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans. Nature 427: 451-457. 14749834