TCDB » SEARCH

View Proteins belonging to: The SIAH1 E3 ubiquitin-protein ligase (SIAH1) Family

8.A.133. The SIAH1 E3 ubiquitin-protein ligase (SIAH1) Family

E3 ubiquitin-protein ligase, Siah1, mediates ubiquitination and subsequent proteasomal degradation of many target proteins (Hu and Fearon 1999). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (Germani et al. 2003). It interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway (Kim et al. 2004). It has some overlapping function with SIAH2 (Pérez et al. 2012; Malz et al. 2012). It also stabilizes or destabilizes various protein targets (Liu et al. 2012). A review focuses on potential multiprotein complexes involving calcium-insensitive S100A10, annexin A2 and several other proteins including AHNAK, dysferlin, NS3, TASK-1 and TRPV5/6 (Rezvanpour and Shaw 2009). The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting the SLC7A11 cystine/glutamate amino acid transporter (TC# 2.A.3.8.18) (Chen et al. 2024).

View Proteins belonging to: The SIAH1 E3 ubiquitin-protein ligase (SIAH1) Family

References associated with 8.A.133 family:

Cai, G., L. Zhu, X. Chen, K. Sun, C. Liu, G.C. Sen, G.R. Stark, J. Qin, and X. Li. (2018). TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation. Proc. Natl. Acad. Sci. USA 115: 11531-11536. 30352854

Chen, Q., T. Zhang, R. Zeng, K. Zhang, B. Li, Z. Zhu, X. Ma, Y. Zhang, L. Li, J. Zhu, and G. Zhang. (2024). The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11. Sci Rep 14: 6655. 38509147

Czechowicz, J.S., C.H. Nagel, M. Voges, M. Spohn, M.M. Eibl, and J. Hauber. (2018). Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo. PLoS One 13: e0201880. 30080903

Fan, W., K.B. Mar, L. Sari, I.K. Gaszek, Q. Cheng, B.M. Evers, J.M. Shelton, M. Wight-Carter, D.J. Siegwart, M.M. Lin, and J.W. Schoggins. (2021). TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity. Cell 184: 3410-3425.e17. 34062120

Germani, A., A. Prabel, S. Mourah, M.P. Podgorniak, A. Di Carlo, R. Ehrlich, S. Gisselbrecht, N. Varin-Blank, F. Calvo, and H. Bruzzoni-Giovanelli. (2003). SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Oncogene 22: 8845-8851. 14654780

Hu, G. and E.R. Fearon. (1999). Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol. Cell Biol. 19: 724-732. 9858595

Kim, H., W. Jeong, K. Ahn, C. Ahn, and S. Kang. (2004). Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway. J Am Soc Nephrol 15: 2042-2049. 15284290

Li, J., P. Wang, Z. Xie, S. Wang, S. Cen, M. Li, W. Liu, S. Tang, G. Ye, G. Zheng, H. Su, M. Ma, X. Wu, Y. Wu, and H. Shen. (2019). TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2. Cell Death Differ 26: 2652-2666. 31076633

Liang, X., J. Xiao, X. Li, Y. Liu, Y. Lu, Y. Wen, Z. Li, X. Che, Y. Ma, X. Zhang, Y. Zhang, D. Jian, P. Wang, C. Xuan, G. Yu, L. Li, and H. Zhang. (2022). A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Nat Chem Biol 18: 1214-1223. 35982226

Liu, M., J. Hsu, C. Chan, Z. Li, and Q. Zhou. (2012). The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol. Cell 46: 325-334. 22483617

Malz, M., A. Aulmann, J. Samarin, M. Bissinger, T. Longerich, S. Schmitt, P. Schirmacher, and K. Breuhahn. (2012). Nuclear accumulation of seven in absentia homologue-2 supports motility and proliferation of liver cancer cells. Int J Cancer 131: 2016-2026. 22323152

Pérez, M., C. García-Limones, I. Zapico, A. Marina, M.L. Schmitz, E. Muñoz, and M.A. Calzado. (2012). Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. J Mol. Cell Biol. 4: 316-330. 22878263

Rezvanpour, A. and G.S. Shaw. (2009). Unique S100 target protein interactions. Gen Physiol Biophys 28SpecNoFocus: F39-46. 20093725

Zhang, M., X. Guan, Z. Dong, C. Yang, C. Xiong, W. Cheng, A. Shang, Y. Liu, X. Guo, B. Zhang, B. Zhang, S. Jin, W. Qi, B.T. Alexandrovna, Y. Jiang, Z. Du, and C. Xu. (2025). Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways. Clin Transl Med 15: e70247. 40000392

Zhang, X., X. Wang, J. Chen, M. Chen, X. Lu, J. Ning, H. Liu, G. Liu, X. Xu, X. Qu, K. Yu, H. Xu, C. Wang, and B. Liu. (2024). Functional analyses of TRAF6 gene in Argopecten scallops. Fish Shellfish Immunol 147: 109443. 38354964