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8.A.133.  The SIAH1 E3 ubiquitin-protein ligase (SIAH1) Family 

E3 ubiquitin-protein ligase, Siah1, mediates ubiquitination and subsequent proteasomal degradation of many target proteins (Hu and Fearon 1999). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (Germani et al. 2003). It interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway (Kim et al. 2004). It has some overlapping function with SIAH2 (Pérez et al. 2012; Malz et al. 2012).  It also stabilizes or destabilizes various protein targets (Liu et al. 2012). A review focuses on potential multiprotein complexes involving calcium-insensitive S100A10, annexin A2 and several other proteins including AHNAK, dysferlin, NS3, TASK-1 and TRPV5/6 (Rezvanpour and Shaw 2009).

References associated with 8.A.133 family:

Czechowicz, J.S., C.H. Nagel, M. Voges, M. Spohn, M.M. Eibl, and J. Hauber. (2018). Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo. PLoS One 13: e0201880. 30080903
Germani, A., A. Prabel, S. Mourah, M.P. Podgorniak, A. Di Carlo, R. Ehrlich, S. Gisselbrecht, N. Varin-Blank, F. Calvo, and H. Bruzzoni-Giovanelli. (2003). SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Oncogene 22: 8845-8851. 14654780
Hu, G. and E.R. Fearon. (1999). Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol. Cell Biol. 19: 724-732. 9858595
Kim, H., W. Jeong, K. Ahn, C. Ahn, and S. Kang. (2004). Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway. J Am Soc Nephrol 15: 2042-2049. 15284290
Liu, M., J. Hsu, C. Chan, Z. Li, and Q. Zhou. (2012). The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol. Cell 46: 325-334. 22483617
Malz, M., A. Aulmann, J. Samarin, M. Bissinger, T. Longerich, S. Schmitt, P. Schirmacher, and K. Breuhahn. (2012). Nuclear accumulation of seven in absentia homologue-2 supports motility and proliferation of liver cancer cells. Int J Cancer 131: 2016-2026. 22323152
Pérez, M., C. García-Limones, I. Zapico, A. Marina, M.L. Schmitz, E. Muñoz, and M.A. Calzado. (2012). Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. J Mol. Cell Biol. 4: 316-330. 22878263
Rezvanpour, A. and G.S. Shaw. (2009). Unique S100 target protein interactions. Gen Physiol Biophys 28SpecNoFocus: F39-46. 20093725