TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.133.1.1









Siah-1 of 282 aas.  It plays roles in the stability and degradation of many proteins (Czechowicz et al. 2018). These include polycystin-1, TrpVs and several other transporters (see family description).

Eukaryota
Metazoa
Siah-1 on Homo sapiens
8.A.133.1.2









Siah-2 of 324 aas.  Seven in absentia homologue-2 (Siah-2) is a host protein that can act as does Siah-1, but with different protein specificities. It mediates the ubiquitination of proteins and is known for its interaction with them to alter their stabilities as affect several cell functions (Malz et al. 2012).

Eukaryota
Metazoa
Siah-2 of Homo sapiens
8.A.133.1.3









E3 ubiquitin-protein ligase SINA-like 9 of 345 aa

Eukaryota
Viridiplantae
SINA-like 9 protein of Elaeis guineensis (African oil palm)
8.A.133.1.4









E3 ubiquitin-protein ligase SINA-like 11 protein of 386 aas and 1 TMS.

Eukaryota
Viridiplantae
SINA-like protein of Oryza sativa Japonica Group (Japanese rice)
8.A.133.1.5









Uncharacterized protein of 270 aas and 2 closely spaced TMSs between residues 66 and 106.

Eukaryota
Metazoa
UP of Xenopus tropicalis (tropical clawed frog)
8.A.133.1.6









Uncharacterized protein of 281 aas and 2 possible TMSs.

Eukaryota
Oomycota
UP of Aphanomyces euteiches
8.A.133.1.7









Uncharacterized protein of 366 aas and possibly 2 TMSs.

Eukaryota
Haptista
UP of Emiliania huxleyi
8.A.133.1.8









E3 ubiquitin-protein ligase RNF114 of 222 aas and maybe 2 N-terminal TM

Eukaryota
Metazoa
Ubiuitin ligase of Microcaecilia unicolor
8.A.133.1.9









Uncharacterized protein of 291 aas and 1 or 2 possible N-terminal TMS(s).

Eukaryota
Fungi
UP of Rhodotorula toruloides
8.A.133.1.10









Uncharacterized protein of 596 aas and 4 C-terminal TMSs in a 2 + 2 TMS arrangement.

Eukaryota
Bacillariophyta
UP of Fragilariopsis cylindrus