8.A.133.1.11
TNF receptor-associated factor 4, TRAF4, of 470 aas and 0 TMSs. It is an adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation,  platelet activation and apoptosis (Cai et al. 2018). It ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain, leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (Li et al. 2019). It has an N-terminal domain similar to those of members of this family, but it has a C-terminal domain similar to sheddases such as that in TC# 8.A.77.2.1.